| pubmed-article:7753871 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7753871 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:7753871 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:7753871 | lifeskim:mentions | umls-concept:C0221464 | lld:lifeskim |
| pubmed-article:7753871 | lifeskim:mentions | umls-concept:C0006685 | lld:lifeskim |
| pubmed-article:7753871 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:7753871 | lifeskim:mentions | umls-concept:C0035028 | lld:lifeskim |
| pubmed-article:7753871 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7753871 | pubmed:dateCreated | 1995-6-16 | lld:pubmed |
| pubmed-article:7753871 | pubmed:abstractText | We have investigated the modifications of cytosolic [Ca2+] and the activity of Ca2+ channels in freshly dispersed arterial myocytes to test whether lowering O2 tension (PO2) directly influences Ca2+ homeostasis in these cells. Unclamped cells loaded with fura-2 AM exhibit oscillations of cytosolic Ca2+ whose frequency depends on extracellular Ca2+ influx. Switching from a PO2 of 150 to 20 mmHg leads to a reversible attenuation of the Ca2+ oscillations. In voltage-clamped cells, hypoxia reversibly reduces the influx of Ca2+ through voltage-dependent channels, which can account for the inhibition of the Ca2+ oscillations. Low PO2 selectively inhibits L-type Ca2+ channel activity, whereas the current mediated by T-type channels is unaltered by hypoxia. The effect of low PO2 on the L-type channels is markedly voltage dependent, being more apparent with moderate depolarizations. These findings demonstrate the existence of O2-sensitive, voltage-dependent, Ca2+ channels in vascular smooth muscle that may critically contribute to the local regulation of circulation. | lld:pubmed |
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| pubmed-article:7753871 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7753871 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7753871 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7753871 | pubmed:month | May | lld:pubmed |
| pubmed-article:7753871 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7753871 | pubmed:author | pubmed-author:López-BarneoJ... | lld:pubmed |
| pubmed-article:7753871 | pubmed:author | pubmed-author:UreñaJJ | lld:pubmed |
| pubmed-article:7753871 | pubmed:author | pubmed-author:Franco-Obregó... | lld:pubmed |
| pubmed-article:7753871 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7753871 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:7753871 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7753871 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7753871 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7753871 | pubmed:pagination | 4715-9 | lld:pubmed |
| pubmed-article:7753871 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7753871 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7753871 | pubmed:articleTitle | Oxygen-sensitive calcium channels in vascular smooth muscle and their possible role in hypoxic arterial relaxation. | lld:pubmed |
| pubmed-article:7753871 | pubmed:affiliation | Departamento de Fisiología Médica y Biofísica, Universidad de Sevilla, Facultad de Medicina, Spain. | lld:pubmed |
| pubmed-article:7753871 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7753871 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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