| pubmed-article:7753823 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0024662 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C1333247 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0205160 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C1158770 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C1417833 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0012591 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0439659 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7753823 | lifeskim:mentions | umls-concept:C1554184 | lld:lifeskim |
| pubmed-article:7753823 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7753823 | pubmed:dateCreated | 1995-6-16 | lld:pubmed |
| pubmed-article:7753823 | pubmed:abstractText | Ear3/COUP is an orphan member of the steroid/thyroid hormone receptor superfamily of transcription factors and binds most tightly to a direct repeat of AGGTCA with 1 nucleotide in between (DR1). Ear3/COUP also binds with a similar affinity to the palindromic thyroid hormone response element (TRE). This binding preference of Ear3/COUP is same as that of the retinoid X receptor (RXR), which is another member of the superfamily. In the present study, we identified a sequence responsible for Ear3/COUP-mediated transactivation in the region downstream of the transcription start site of the mouse mammary tumor virus promoter. This cis-acting sequence was unresponsive to RXR. When the DR1 or TRE sequence was added upstream of the promoter, transactivation by Ear3/COUP was completely abolished, whereas RXR enhanced transcription from the promoter. The mode of action of Ear3/COUP could be utilized to control complex gene expressions in morphogenesis, homeostasis, and development. | lld:pubmed |
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| pubmed-article:7753823 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7753823 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7753823 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7753823 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7753823 | pubmed:month | May | lld:pubmed |
| pubmed-article:7753823 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7753823 | pubmed:author | pubmed-author:YamamotoTT | lld:pubmed |
| pubmed-article:7753823 | pubmed:author | pubmed-author:ToyoshimaKK | lld:pubmed |
| pubmed-article:7753823 | pubmed:author | pubmed-author:KadowakiYY | lld:pubmed |
| pubmed-article:7753823 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7753823 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:7753823 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7753823 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7753823 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7753823 | pubmed:pagination | 4432-6 | lld:pubmed |
| pubmed-article:7753823 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7753823 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7753823 | pubmed:articleTitle | Dual transcriptional control by Ear3/COUP: negative regulation through the DR1 direct repeat and positive regulation through a sequence downstream of the transcriptional start site of the mouse mammary tumor virus promoter. | lld:pubmed |
| pubmed-article:7753823 | pubmed:affiliation | Department of Oncology, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:7753823 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7753823 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:11819 | entrezgene:pubmed | pubmed-article:7753823 | lld:entrezgene |
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