| pubmed-article:7752573 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0205111 | lld:lifeskim |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0227662 | lld:lifeskim |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0037473 | lld:lifeskim |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0033727 | lld:lifeskim |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0678640 | lld:lifeskim |
| pubmed-article:7752573 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:7752573 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7752573 | pubmed:dateCreated | 1995-6-22 | lld:pubmed |
| pubmed-article:7752573 | pubmed:abstractText | These studies were performed to determine if changes in luminal sodium chloride concentration ([NaCl]) might alter macula densa intracellular pH. Isolated thick ascending limbs with attached glomeruli were bathed in a 150 mM NaCl Ringer's solution and perfused in vitro with a 25 mM NaCl solution; N-methyl-D-glucamine cyclamate was used to substitute for NaCl. Macula densa cells were loaded with BCECF and intracellular pH was monitored using a microscope based-dual excitation photometer system. Control intracellular pH for all experiments in which tubules were initially perfused with 25 mM NaCl averaged 7.22 +/- 0.06; N = 28. Increasing luminal [NaCl] from 25 to 150 mM elevated macula densa pH by 0.15 +/- 0.03 (N = 6; P < 0.05) while increasing just luminal [Na] from 25 to 150 mM alkalinized macula densa cells by 0.17 +/- 0.05 (N = 6; P < 0.05). In addition, there was a highly significant linear relationship between luminal [Na] and intracellular pH between 25 and 150 mM NaCl. Other studies were performed to assess the effects of amiloride, an inhibitor of Na:H exchange, on macula densa intracellular pH. Addition of amiloride, to the 25 mM NaCl perfusate acidified macula densa cells by 0.09 +/- 0.03 (N = 6; P < 0.001) and significantly attenuated the increase in pH obtained when luminal [NaCl] was raised from 25 to 150 mM. Other studies evaluated the effects of inhibition of Na:2Cl:K cotransport on macula densa pH.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
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| pubmed-article:7752573 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7752573 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7752573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7752573 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7752573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7752573 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7752573 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7752573 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7752573 | pubmed:issn | 0085-2538 | lld:pubmed |
| pubmed-article:7752573 | pubmed:author | pubmed-author:BellP DPD | lld:pubmed |
| pubmed-article:7752573 | pubmed:author | pubmed-author:ChangY SYS | lld:pubmed |
| pubmed-article:7752573 | pubmed:author | pubmed-author:LapointeJ YJY | lld:pubmed |
| pubmed-article:7752573 | pubmed:author | pubmed-author:HigdonMM | lld:pubmed |
| pubmed-article:7752573 | pubmed:author | pubmed-author:FowlerB CBC | lld:pubmed |
| pubmed-article:7752573 | pubmed:author | pubmed-author:LaamartiAA | lld:pubmed |
| pubmed-article:7752573 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7752573 | pubmed:volume | 47 | lld:pubmed |
| pubmed-article:7752573 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7752573 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7752573 | pubmed:pagination | 746-51 | lld:pubmed |
| pubmed-article:7752573 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7752573 | pubmed:meshHeading | pubmed-meshheading:7752573-... | lld:pubmed |
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| pubmed-article:7752573 | pubmed:meshHeading | pubmed-meshheading:7752573-... | lld:pubmed |
| pubmed-article:7752573 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7752573 | pubmed:articleTitle | Evidence for apical sodium proton exchange in macula densa cells. | lld:pubmed |
| pubmed-article:7752573 | pubmed:affiliation | Department of Medicine, University of Alabama at Birmingham, USA. | lld:pubmed |
| pubmed-article:7752573 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7752573 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7752573 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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