| pubmed-article:7735970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7735970 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7735970 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:7735970 | lifeskim:mentions | umls-concept:C0001962 | lld:lifeskim |
| pubmed-article:7735970 | lifeskim:mentions | umls-concept:C0376618 | lld:lifeskim |
| pubmed-article:7735970 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:7735970 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7735970 | pubmed:dateCreated | 1995-6-7 | lld:pubmed |
| pubmed-article:7735970 | pubmed:abstractText | The effect of acute ethanol administration on the hepatic microvascular responses to sepsis was studied. Polymicrobial sepsis was induced 30 min after mice had received ethanol (1 g/kg b.w.) or isocaloric maltose-dextrin by gastric gavage. Lethality within 24 h was 91.7% in the ethanol-treated animals and 40.0% in septic controls. Endotoxin levels in ethanol treated animals were 107 pg/ml at 6 hr and 1205 pg/ml at 12 h, compared with 32 pg/ml and 104 pg/ml, respectively in the controls. In vivo microscopy revealed that at 3 h in the ethanol treated septic animals, Kupffer cell phagocytic activity was increased by 41%, whereas the number of sinusoids containing blood flow were reduced by 34% concomitant with a 144% increase in the adherence of leukocytes to the sinusoidal walls when compared with the septic controls. By 6 h, however, Kupffer cell phagocytic activity was reduced by 48% in the ethanol treated animals; this was accompanied by a further deterioration in sinusoidal blood flow. Thus, a small, acute dose of ethanol causes significant impairment of the hepatic microcirculation followed by suppression of Kupffer cell activity. This results in exacerbation of endotoxemia and lethality during polymicrobial sepsis. | lld:pubmed |
| pubmed-article:7735970 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7735970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7735970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7735970 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7735970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7735970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7735970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7735970 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7735970 | pubmed:issn | 1073-2322 | lld:pubmed |
| pubmed-article:7735970 | pubmed:author | pubmed-author:UrbaschekBB | lld:pubmed |
| pubmed-article:7735970 | pubmed:author | pubmed-author:McDonnellDD | lld:pubmed |
| pubmed-article:7735970 | pubmed:author | pubmed-author:McCuskeyR SRS | lld:pubmed |
| pubmed-article:7735970 | pubmed:author | pubmed-author:NishideFF | lld:pubmed |
| pubmed-article:7735970 | pubmed:author | pubmed-author:UrbaschekRR | lld:pubmed |
| pubmed-article:7735970 | pubmed:author | pubmed-author:EkataksinWW | lld:pubmed |
| pubmed-article:7735970 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7735970 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:7735970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7735970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7735970 | pubmed:pagination | 413-8 | lld:pubmed |
| pubmed-article:7735970 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:meshHeading | pubmed-meshheading:7735970-... | lld:pubmed |
| pubmed-article:7735970 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7735970 | pubmed:articleTitle | Ethanol exacerbates hepatic microvascular dysfunction, endotoxemia, and lethality in septic mice. | lld:pubmed |
| pubmed-article:7735970 | pubmed:affiliation | Department of Anatomy, College of Medicine, University of Arizona, Tucson 85724, USA. | lld:pubmed |
| pubmed-article:7735970 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7735970 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7735970 | lld:pubmed |
