| pubmed-article:7711112 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7711112 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7711112 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7711112 | lifeskim:mentions | umls-concept:C2826170 | lld:lifeskim |
| pubmed-article:7711112 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7711112 | pubmed:dateCreated | 1995-5-17 | lld:pubmed |
| pubmed-article:7711112 | pubmed:abstractText | For several decades simian virus 40 (SV40) early region genes have been used as a means of generating immortalized human cell lines; however, the molecular mechanisms of this process have begun to be understood only recently. SV40-induced immortalization proceeds via two phases. In the first phase ("lifespan extension"), cells continue proliferating for a limited number of population doublings beyond the point at which normal cells undergo senescence. This is mainly due to the ability of SV40 large T antigen (LTAg) to bind to the protein products of the p53 and retinoblastoma (Rb) genes. The second phase ("immortalization") occurs in only a small minority of cells, and cell hybridization analyses indicate that this is a gene inactivation event. The gene or genes involved are currently unknown, but chromosomal localization data are accumulating which should make their cloning and characterization possible in the near future. | lld:pubmed |
| pubmed-article:7711112 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7711112 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7711112 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7711112 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7711112 | pubmed:issn | 0893-9675 | lld:pubmed |
| pubmed-article:7711112 | pubmed:author | pubmed-author:BryanT MTM | lld:pubmed |
| pubmed-article:7711112 | pubmed:author | pubmed-author:ReddelR RRR | lld:pubmed |
| pubmed-article:7711112 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7711112 | pubmed:volume | 5 | lld:pubmed |
| pubmed-article:7711112 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7711112 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7711112 | pubmed:pagination | 331-57 | lld:pubmed |
| pubmed-article:7711112 | pubmed:dateRevised | 2005-11-16 | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:meshHeading | pubmed-meshheading:7711112-... | lld:pubmed |
| pubmed-article:7711112 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7711112 | pubmed:articleTitle | SV40-induced immortalization of human cells. | lld:pubmed |
| pubmed-article:7711112 | pubmed:affiliation | Children's Medical Research Institute, Sydney, NSW, Australia. | lld:pubmed |
| pubmed-article:7711112 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7711112 | pubmed:publicationType | Review | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7711112 | lld:pubmed |
