| pubmed-article:7708727 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C1135183 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0450127 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0021764 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C1521991 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7708727 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7708727 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7708727 | pubmed:dateCreated | 1995-5-11 | lld:pubmed |
| pubmed-article:7708727 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7708727 | pubmed:abstractText | Clones encoding porcine interleukin 10 (IL-10) were isolated from a cDNA library produced from phytohemagglutinin-activated pig peripheral blood mononuclear cells. The porcine IL-10 nucleotide sequence was found to be highly homologous to the rat, mouse, and human IL-10 counterparts and to one of the open reading frames from the Epstein-Barr virus. In addition, pig IL-10 caused inhibition of gamma-interferon gene transcription as determined by a bioassay. To investigate the possible immunomodulatory role of IL-10, its expression during the induction of tolerance to kidney allografts by cyclosporin A in miniature swine was also investigated. Delayed expression and higher levels of IL-10 were observed in tolerant animals compared with animals rejecting their allografts. Since tolerance is achieved by a short course of cyclosporin A, we have also studied the in vitro effect of this drug on IL-10 gene transcription in blood mononuclear cells and have found that cyclosporin A inhibits IL-10 gene activation in T cells but does not interfere with IL-10 transcription in lipopolysaccharide-activated cells. These results suggest that the overexpression of IL-10, observed in cell populations infiltrating grafts from tolerant animals, may be a function of monocytes and/or B cells. | lld:pubmed |
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| pubmed-article:7708727 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7708727 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7708727 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7708727 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7708727 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7708727 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7708727 | pubmed:author | pubmed-author:SachsD HDH | lld:pubmed |
| pubmed-article:7708727 | pubmed:author | pubmed-author:BlanchoGG | lld:pubmed |
| pubmed-article:7708727 | pubmed:author | pubmed-author:LeGuernCC | lld:pubmed |
| pubmed-article:7708727 | pubmed:author | pubmed-author:GermanaSS | lld:pubmed |
| pubmed-article:7708727 | pubmed:author | pubmed-author:BaetscherMM | lld:pubmed |
| pubmed-article:7708727 | pubmed:author | pubmed-author:GianelloPP | lld:pubmed |
| pubmed-article:7708727 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7708727 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7708727 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7708727 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7708727 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7708727 | pubmed:pagination | 2800-4 | lld:pubmed |
| pubmed-article:7708727 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7708727 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7708727 | pubmed:articleTitle | Molecular identification of porcine interleukin 10: regulation of expression in a kidney allograft model. | lld:pubmed |
