| pubmed-article:7695293 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0043474 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0021051 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0021289 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0087111 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0024398 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C1838994 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0205253 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0332162 | lld:lifeskim |
| pubmed-article:7695293 | lifeskim:mentions | umls-concept:C0449435 | lld:lifeskim |
| pubmed-article:7695293 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7695293 | pubmed:dateCreated | 1995-4-26 | lld:pubmed |
| pubmed-article:7695293 | pubmed:abstractText | Simian immunodeficiency virus (SIV) infection of newborn rhesus macaques is a practical animal model of pediatric AIDS. Intravenous inoculation of rhesus newborns with uncloned SIVmac resulted in a high virus load, no antiviral immune responses, severe immunodeficiency, and a high mortality rate within 3 months. In contrast, immediate oral zidovudine (AZT) treatment of SIV-inoculated rhesus newborns either prevented infection or resulted in reduced virus load, enhanced antiviral immune responses, a low frequency of AZT-resistant virus isolates, and delayed disease progression with negligible toxicity. These results suggest that early chronic AZT treatment of human immunodeficiency virus-exposed newborns may have benefits that outweigh its potential side effects. | lld:pubmed |
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| pubmed-article:7695293 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7695293 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7695293 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7695293 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7695293 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:7695293 | pubmed:author | pubmed-author:PedersenN CNC | lld:pubmed |
| pubmed-article:7695293 | pubmed:author | pubmed-author:MillerC JCJ | lld:pubmed |
| pubmed-article:7695293 | pubmed:author | pubmed-author:McChesneyM... | lld:pubmed |
| pubmed-article:7695293 | pubmed:author | pubmed-author:MarthasM LML | lld:pubmed |
| pubmed-article:7695293 | pubmed:author | pubmed-author:Van RompayK... | lld:pubmed |
| pubmed-article:7695293 | pubmed:author | pubmed-author:OtsyulaM GMG | lld:pubmed |
| pubmed-article:7695293 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7695293 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:7695293 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7695293 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7695293 | pubmed:pagination | 125-31 | lld:pubmed |
| pubmed-article:7695293 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7695293 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7695293 | pubmed:articleTitle | Immediate zidovudine treatment protects simian immunodeficiency virus-infected newborn macaques against rapid onset of AIDS. | lld:pubmed |
| pubmed-article:7695293 | pubmed:affiliation | California Regional Primate Research Center, University of California, Davis 95616. | lld:pubmed |
| pubmed-article:7695293 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7695293 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7695293 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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