| pubmed-article:7692082 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7692082 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:7692082 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:7692082 | lifeskim:mentions | umls-concept:C0913822 | lld:lifeskim |
| pubmed-article:7692082 | lifeskim:mentions | umls-concept:C0913823 | lld:lifeskim |
| pubmed-article:7692082 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:7692082 | pubmed:dateCreated | 1993-11-24 | lld:pubmed |
| pubmed-article:7692082 | pubmed:abstractText | Vaccination against human immunodeficiency virus type 1 (HIV-1) requires an immunogen which will elicit a protective immunity against viruses that show a high degree of genetic polymorphism. Therefore, the identification of neutralizing epitopes which are shared by many strains would be useful. In previous studies, we established a human monoclonal antibody (2F5) that neutralizes a variety of laboratory strains and clinical isolates of HIV-1. In the present report, we define the amino acid sequence Glu-Leu-Asp-Lys-Trp-Ala (ELDKWA) on the ectodomain of gp41 as the epitope recognized by this antibody. The sequence was found to be conserved in 72% of otherwise highly variable HIV-1 isolates. Escape mutants were not detected in cells infected with HIV-1 isolates MN and RF in the presence of antibody 2F5. Since sequence variability of neutralizing epitopes is considered to be a major obstacle to HIV-1 vaccine development, the conserved B-cell epitope described here is a promising candidate for inclusion in a vaccine against AIDS. | lld:pubmed |
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| pubmed-article:7692082 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7692082 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7692082 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7692082 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7692082 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7692082 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:KatingerHH | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:SteindlFF | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:TrkolaAA | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:RükerFF | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:KlimaAA | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:HimmlerGG | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:MusterTT | lld:pubmed |
| pubmed-article:7692082 | pubmed:author | pubmed-author:PurtscherMM | lld:pubmed |
| pubmed-article:7692082 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7692082 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:7692082 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7692082 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7692082 | pubmed:pagination | 6642-7 | lld:pubmed |
| pubmed-article:7692082 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7692082 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7692082 | pubmed:articleTitle | A conserved neutralizing epitope on gp41 of human immunodeficiency virus type 1. | lld:pubmed |
| pubmed-article:7692082 | pubmed:affiliation | Institut für Angewandte Mikrobiologie, Universität für Bodenkultur, Wien, Austria. | lld:pubmed |
| pubmed-article:7692082 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7692082 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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