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pubmed-article:7691301pubmed:abstractTextLymphocyte subset abnormalities have been observed in a series of patients diagnosed with Wegener's granulomatosis (WG). Fifteen patients with WG were evaluated for lymphocyte subset abnormalities by two-color immunofluorescence flow cytometry. The WG group showed a decrease in CD4+ cells and an extraordinary increase in HLA-DR+ cells. The average percentages of HLA-DR+ cells of the normal group and WG group were 11.0 +/- 4.0 and 40.5 +/- 13.9% (CD3+HLA-DR+ = 20.3 + 9.4%). Within the CD8 family, CD8+57+, CD8+38+ and CD8+HLA-DR+ cells were markedly elevated. Our findings differ from other series which reported that the lymphocyte subsets in the peripheral blood of patients with WG were normal.lld:pubmed
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pubmed-article:7691301pubmed:dateRevised2006-11-15lld:pubmed
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pubmed-article:7691301pubmed:articleTitleDistinctive increases in HLA-DR+ and CD8+57+ lymphocyte subsets in Wegener's granulomatosis.lld:pubmed
pubmed-article:7691301pubmed:affiliationDepartment of Otolaryngology, National Defense Medical College, Saitama, Japan.lld:pubmed
pubmed-article:7691301pubmed:publicationTypeJournal Articlelld:pubmed