| pubmed-article:7689617 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7689617 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7689617 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:7689617 | lifeskim:mentions | umls-concept:C0003241 | lld:lifeskim |
| pubmed-article:7689617 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:7689617 | lifeskim:mentions | umls-concept:C0075290 | lld:lifeskim |
| pubmed-article:7689617 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7689617 | pubmed:dateCreated | 1993-9-28 | lld:pubmed |
| pubmed-article:7689617 | pubmed:abstractText | There is evidence suggesting that Sydenham's chorea, which is a major manifestation of acute rheumatic fever, may be mediated by streptococcal antibodies that cross-react with the brain. Our studies were undertaken to determine whether streptococcal M protein, the major virulence factor of group A streptococci, evoked antibodies that cross-react with human brain. Rabbits were immunized with pepsin-extracted M protein from rheumatogenic type 6 streptococci. Immune sera were screened for the presence of antibodies that cross-reacted with human brain by indirect immunofluorescence tests and immunoblot analyses. Type 6 M protein evoked antibodies that cross-reacted with several brain proteins and antibody binding to these proteins was completely inhibited by type 6 M protein and partially inhibited by types 5 and 19 M proteins, suggesting that these heterologous M proteins contain conserved brain-cross-reactive epitopes. Using synthetic peptides from several serotypes of M proteins, the conserved brain-cross-reactive epitopes were localized to a decapeptide contained within the covalent structure of the B repeat region of type 6 M protein. These peptides also inhibited brain-cross-reactive antibodies in the serum of a patient with active Sydenham's chorea. Our data indicate that streptococcal M proteins contain brain-cross-reactive epitopes that could potentially be involved in the pathogenesis of Sydenham's chorea. | lld:pubmed |
| pubmed-article:7689617 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689617 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7689617 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7689617 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7689617 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7689617 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7689617 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7689617 | pubmed:author | pubmed-author:DaleJ BJB | lld:pubmed |
| pubmed-article:7689617 | pubmed:author | pubmed-author:BronzeM SMS | lld:pubmed |
| pubmed-article:7689617 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7689617 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7689617 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:7689617 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7689617 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7689617 | pubmed:pagination | 2820-8 | lld:pubmed |
| pubmed-article:7689617 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7689617 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7689617 | pubmed:articleTitle | Epitopes of streptococcal M proteins that evoke antibodies that cross-react with human brain. | lld:pubmed |
| pubmed-article:7689617 | pubmed:affiliation | Department of Veterans Affairs Medical Center, Memphis, TN. | lld:pubmed |
| pubmed-article:7689617 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7689617 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7689617 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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