| pubmed-article:7684618 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7684618 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:7684618 | lifeskim:mentions | umls-concept:C0439861 | lld:lifeskim |
| pubmed-article:7684618 | lifeskim:mentions | umls-concept:C0003286 | lld:lifeskim |
| pubmed-article:7684618 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:7684618 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7684618 | pubmed:dateCreated | 1993-7-1 | lld:pubmed |
| pubmed-article:7684618 | pubmed:abstractText | In the present study, we examine the involvement of the L-arginine-nitric oxide pathway in seizure activity termination. Convulsions were induced reproducibly by intracerebroventricular administration of N-methyl-D-aspartate to conscious mice. The duration of the seizure activity was increased by inhibition of the NO-pathway or by intracerebroventricular injection of methylene blue, an inhibitor of guanylate cyclase activity. This increased duration in seizure activity was reversed by co-administration of L-arginine or by intracerebroventricular injection of guanosine 3':5' cyclic monophosphate (cGMP). These results suggest that nitric oxide produced in response to NMDA receptor activation leads to an increase in cGMP which induces the seizure activity termination. | lld:pubmed |
| pubmed-article:7684618 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7684618 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684618 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7684618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684618 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684618 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7684618 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7684618 | pubmed:issn | 0959-4965 | lld:pubmed |
| pubmed-article:7684618 | pubmed:author | pubmed-author:PlotkineMM | lld:pubmed |
| pubmed-article:7684618 | pubmed:author | pubmed-author:BouluR GRG | lld:pubmed |
| pubmed-article:7684618 | pubmed:author | pubmed-author:BuissonAA | lld:pubmed |
| pubmed-article:7684618 | pubmed:author | pubmed-author:VerrecchiaCC | lld:pubmed |
| pubmed-article:7684618 | pubmed:author | pubmed-author:LakhmecheNN | lld:pubmed |
| pubmed-article:7684618 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7684618 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:7684618 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7684618 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7684618 | pubmed:pagination | 444-6 | lld:pubmed |
| pubmed-article:7684618 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:meshHeading | pubmed-meshheading:7684618-... | lld:pubmed |
| pubmed-article:7684618 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7684618 | pubmed:articleTitle | Nitric oxide: an endogenous anticonvulsant substance. | lld:pubmed |
| pubmed-article:7684618 | pubmed:affiliation | Laboratoire de Pharmacologie, Faculté des Sciences Pharmaceutiques et Biologiques, Université René Descartes, Paris, France. | lld:pubmed |
| pubmed-article:7684618 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7684618 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7684618 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7684618 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7684618 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7684618 | lld:pubmed |
