| pubmed-article:7684194 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C1413234 | lld:lifeskim |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:7684194 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:7684194 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7684194 | pubmed:dateCreated | 1993-6-14 | lld:pubmed |
| pubmed-article:7684194 | pubmed:abstractText | A new anti-macrophage monoclonal antibody (PG-M1) was produced by immunizing BALB/c mice with fresh spleen cells from a patient with Gaucher's disease. PG-M1 reacts strongly with a fixative-resistant epitope of an intracytoplasmic molecule, selectively expressed by virtually all macrophages of the human body. Although attempts to immunoprecipitate the molecule recognized by PG-M1 have failed so far, the reactivity of the antibody with COS-1 and WOP cells transfected with a human complementary DNA clone encoding for the CD68 antigen suggests that PG-M1 is a new member of the CD68 cluster. However, unlike other CD68 antibodies (KP1, EBM11, etc.), which react with both macrophages and myeloid cells, PG-M1 detects a fixative-resistant epitope on the macrophage-restricted form of the CD68 antigen. In 957 routinely fixed, paraffin-embedded samples, PG-M1 showed a more restricted reactivity with elements of the monocyte/macrophage lineage than the previously described monoclonal antibodies MAC-387 (anti-calgranulins), KP1 (CD68) and Ki-M1P. Among hematological malignancies, PG-M1 only labels acute leukemias of M4 and M5 type and rare examples of malignant histiocytosis/true histiocytic sarcoma. In contrast, acute leukemias of the M1, M2, M3, M6, M7, and L1-L3 types, non-Hodgkin's lymphomas, and Hodgkin and Reed-Sternberg cells of Hodgkin's disease are consistently PG-M1-negative. In the daily diagnostic practice, PG-M1 seems to be particularly valuable for the diagnosis of myelomonocytic or monocytic leukemia and neoplasms of true histiocytic origin in routine paraffin sections. | lld:pubmed |
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| pubmed-article:7684194 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7684194 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684194 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7684194 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7684194 | pubmed:month | May | lld:pubmed |
| pubmed-article:7684194 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:GambacortaMM | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:ThieleJJ | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:CavalieriEE | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:PileriSS | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:FaliniBB | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:EitelbachFF | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:FlenghiLL | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:BigernaBB | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:PaciniRR | lld:pubmed |
| pubmed-article:7684194 | pubmed:author | pubmed-author:DurkopHH | lld:pubmed |
| pubmed-article:7684194 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7684194 | pubmed:volume | 142 | lld:pubmed |
| pubmed-article:7684194 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7684194 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7684194 | pubmed:pagination | 1359-72 | lld:pubmed |
| pubmed-article:7684194 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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