| pubmed-article:7684005 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7684005 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7684005 | lifeskim:mentions | umls-concept:C0449475 | lld:lifeskim |
| pubmed-article:7684005 | lifeskim:mentions | umls-concept:C1518286 | lld:lifeskim |
| pubmed-article:7684005 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:7684005 | lifeskim:mentions | umls-concept:C1826396 | lld:lifeskim |
| pubmed-article:7684005 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:7684005 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7684005 | pubmed:dateCreated | 1993-6-11 | lld:pubmed |
| pubmed-article:7684005 | pubmed:abstractText | The c-Myb transcription factor regulates the differentiation of immature erythroid, lymphoid, and myeloid cells, although only the latter cells become transformed by the v-myb oncogene. These are also the only cells that express the Myb-regulated gene mim-1, suggesting that Myb requires tissue-specific, cooperating factors to activate such genes. Here, we investigated the tissue-specific regulation of the mim-1 promoter and found that it not only contains binding sites for Myb but also for NF-M, a myeloid-specific transcription factor that probably corresponds to mammalian C/EBP beta. Both types of binding sites were found to be required for full activity of the promoter. Remarkably, ectopic coexpression of Myb and NF-M proteins in erythroid cells or fibroblasts was sufficient to induce endogenous markers of myeloid differentiation, like the mim-1 and lysozyme genes. Our results indicate that c-Myb and NF-M proteins act as a bipartite, combinatorial signal that regulates the expression of myeloid-specific genes, even in heterologous cell types. | lld:pubmed |
| pubmed-article:7684005 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7684005 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7684005 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7684005 | pubmed:month | May | lld:pubmed |
| pubmed-article:7684005 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:7684005 | pubmed:author | pubmed-author:GradJJ | lld:pubmed |
| pubmed-article:7684005 | pubmed:author | pubmed-author:CasiniTT | lld:pubmed |
| pubmed-article:7684005 | pubmed:author | pubmed-author:LeutzAA | lld:pubmed |
| pubmed-article:7684005 | pubmed:author | pubmed-author:Kowenz-LeutzE... | lld:pubmed |
| pubmed-article:7684005 | pubmed:author | pubmed-author:NessS ASA | lld:pubmed |
| pubmed-article:7684005 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7684005 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:7684005 | pubmed:geneSymbol | mim-1 | lld:pubmed |
| pubmed-article:7684005 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7684005 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7684005 | pubmed:pagination | 749-59 | lld:pubmed |
| pubmed-article:7684005 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7684005 | pubmed:meshHeading | pubmed-meshheading:7684005-... | lld:pubmed |
| pubmed-article:7684005 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7684005 | pubmed:articleTitle | Myb and NF-M: combinatorial activators of myeloid genes in heterologous cell types. | lld:pubmed |
| pubmed-article:7684005 | pubmed:affiliation | Zentrum für Molekulare Biologie, Universität Heidelberg (ZMBH), Germany. | lld:pubmed |
| pubmed-article:7684005 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7684005 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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