| pubmed-article:7683388 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7683388 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7683388 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:7683388 | lifeskim:mentions | umls-concept:C0242609 | lld:lifeskim |
| pubmed-article:7683388 | lifeskim:mentions | umls-concept:C0026006 | lld:lifeskim |
| pubmed-article:7683388 | lifeskim:mentions | umls-concept:C1511790 | lld:lifeskim |
| pubmed-article:7683388 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7683388 | pubmed:dateCreated | 1993-5-28 | lld:pubmed |
| pubmed-article:7683388 | pubmed:abstractText | A modified micronucleus assay using antikinetochore antibody has been developed in cytokinesis-blocked human fibroblasts as a simple method to identify aneuploidy-inducing agents. Different protocols for inducing binucleated cells by cytochalasin B in colchicine-treated human fibroblasts were investigated. A dose-related increase in kinetochore-positive micronuclei was obtained when cytochalasin B was given subsequent to colchicine treatment. No induction of micronuclei was observed in combined treatments of the two substances. These results indicate that the detection of kinetochores in micronucleated cytokinesis-blocked human fibroblasts can be effectively applied to the identification of environmental agents with aneuploidy-inducing potential. However, in testing such compounds particular attention should be paid to the protocol used for inducing cytokinesis-blocked cells. | lld:pubmed |
| pubmed-article:7683388 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7683388 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7683388 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7683388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7683388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7683388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7683388 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7683388 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7683388 | pubmed:month | May | lld:pubmed |
| pubmed-article:7683388 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:7683388 | pubmed:author | pubmed-author:TanzarellaCC | lld:pubmed |
| pubmed-article:7683388 | pubmed:author | pubmed-author:AntocciaAA | lld:pubmed |
| pubmed-article:7683388 | pubmed:author | pubmed-author:DegrassiFF | lld:pubmed |
| pubmed-article:7683388 | pubmed:author | pubmed-author:ModestoJJ | lld:pubmed |
| pubmed-article:7683388 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7683388 | pubmed:volume | 287 | lld:pubmed |
| pubmed-article:7683388 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7683388 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7683388 | pubmed:pagination | 93-9 | lld:pubmed |
| pubmed-article:7683388 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:meshHeading | pubmed-meshheading:7683388-... | lld:pubmed |
| pubmed-article:7683388 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7683388 | pubmed:articleTitle | Cytokinesis-block micronucleus assay with kinetochore detection in colchicine-treated human fibroblasts. | lld:pubmed |
| pubmed-article:7683388 | pubmed:affiliation | Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, Rome, Italy. | lld:pubmed |
| pubmed-article:7683388 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7683388 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
