| pubmed-article:7650396 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0002092 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0214743 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7650396 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7650396 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7650396 | pubmed:dateCreated | 1995-9-22 | lld:pubmed |
| pubmed-article:7650396 | pubmed:abstractText | Atopic asthma is characterized by inflammatory responses of the airway and is associated with up-regulation of Th2 cytokines, notably IL-4 and IL-5. A recently described human cytokine, IL-13, is a potent in vitro modulator of various cell types, including monocytes, B cells, and endothelial cells. Similar to IL-4, it is also involved in the induction of IgE synthesis. However, the in vivo expression and function of IL-13 and its relation to disease remain to be defined. Using a segmental allergen challenge model, we have examined the in vivo expression of IL-13 in the bronchoalveolar lavage (BAL) cells of atopic patients. We found a significant enhancement of both IL-13 transcripts and secreted proteins in the allergen-challenged BAL compared with the saline-challenged control sites of asthmatic and rhinitic patients. In contrast, the expression of IL-13 transcripts was not detected in the BAL of two normal subjects challenged with the same dose of ragweed allergen. The cellular source of IL-13 mRNA was identified in the mononuclear cell fraction of the allergen-challenged BAL. The allergen-induced quantitative differences in the level of transcripts were confirmed by competitive PCR assays. These results suggest that the significant increase in IL-13 in the allergen-challenged BAL is primarily from the mononuclear cells and is involved in the regulation of allergen-induced late phase inflammatory responses. | lld:pubmed |
| pubmed-article:7650396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650396 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650396 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7650396 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7650396 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7650396 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7650396 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7650396 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:LichtensteinL... | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:MarshD GDG | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:LiuM CMC | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:HuangS KSK | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:Kleine-TebbeJ... | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:XiaoH QHQ | lld:pubmed |
| pubmed-article:7650396 | pubmed:author | pubmed-author:PaciottiGG | lld:pubmed |
| pubmed-article:7650396 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7650396 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7650396 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:7650396 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7650396 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7650396 | pubmed:pagination | 2688-94 | lld:pubmed |
| pubmed-article:7650396 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7650396 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7650396 | pubmed:articleTitle | IL-13 expression at the sites of allergen challenge in patients with asthma. | lld:pubmed |
| pubmed-article:7650396 | pubmed:affiliation | Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224, USA. | lld:pubmed |
| pubmed-article:7650396 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7650396 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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