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| pubmed-article:7649477 | lifeskim:mentions | umls-concept:C0034678 | lld:lifeskim |
| pubmed-article:7649477 | lifeskim:mentions | umls-concept:C0058402 | lld:lifeskim |
| pubmed-article:7649477 | lifeskim:mentions | umls-concept:C1539630 | lld:lifeskim |
| pubmed-article:7649477 | lifeskim:mentions | umls-concept:C0597360 | lld:lifeskim |
| pubmed-article:7649477 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7649477 | lifeskim:mentions | umls-concept:C0439831 | lld:lifeskim |
| pubmed-article:7649477 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:7649477 | pubmed:dateCreated | 1995-9-28 | lld:pubmed |
| pubmed-article:7649477 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7649477 | pubmed:abstractText | We have used differential display PCR to search for mRNAs induced by delta Raf-1:ER, an estradiol-dependent form of Raf-1 kinase. Through this approach the gene encoding heparin-binding epidermal growth factor (HB-EGF) was identified as an immediate-early transcriptional target of oncogenic Raf kinases. Activation of delta Raf-1:ER and a conditional oncogenic form of B-Raf, delta B-RAF:ER, resulted in rapid and sustained induction of HB-EGF mRNA expression and secretion of mature HB-EGF from cells. Neutralizing anti-HB-EGF antisera prevented the delayed activation of the c-Jun amino-terminal kinases that is observed in cells transformed by delta Raf-1:ER. These results demonstrate that distinct signaling pathways can cross talk via the secretion of polypeptide growth factors. Furthermore, cells transformed by oncogenic Ras, which also induced HB-EGF expression, demonstrated a marked increase in sensitivity to the cytotoxic action of diphtheria toxin, for which the membrane anchored HB-EGF precursor acts as a cell-surface receptor. | lld:pubmed |
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| pubmed-article:7649477 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7649477 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7649477 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7649477 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7649477 | pubmed:issn | 0890-9369 | lld:pubmed |
| pubmed-article:7649477 | pubmed:author | pubmed-author:SamuelsM LML | lld:pubmed |
| pubmed-article:7649477 | pubmed:author | pubmed-author:PritchardC... | lld:pubmed |
| pubmed-article:7649477 | pubmed:author | pubmed-author:McMahonMM | lld:pubmed |
| pubmed-article:7649477 | pubmed:author | pubmed-author:McCarthyS ASA | lld:pubmed |
| pubmed-article:7649477 | pubmed:author | pubmed-author:AbrahamJ AJA | lld:pubmed |
| pubmed-article:7649477 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7649477 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7649477 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:7649477 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7649477 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7649477 | pubmed:pagination | 1953-64 | lld:pubmed |
| pubmed-article:7649477 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7649477 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7649477 | pubmed:articleTitle | Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes. | lld:pubmed |
| pubmed-article:7649477 | pubmed:affiliation | DNAX Research Institute, Palo Alto, California 94304, USA. | lld:pubmed |
| pubmed-article:7649477 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7649477 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7649477 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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