| pubmed-article:7646893 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0040704 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0687129 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0028128 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0034143 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0007765 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0011570 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C1274040 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7646893 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:7646893 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7646893 | pubmed:dateCreated | 1995-9-28 | lld:pubmed |
| pubmed-article:7646893 | pubmed:abstractText | The role of nitric oxide (NO) in the induction of long-term depression (LTD) in the cerebellum was explored using a new, organic, membrane-impermeant form of caged NO. NO photolytically released inside Purkinje neurons mimicked parallel fiber (PF) activity in synergizing with brief postsynaptic depolarization to induce LTD. Such LTD required a delay of < 50 ms between the end of photolysis and the onset of depolarization, was prevented by intracellular Ca2+ chelation, and was mutually occlusive with LTD conventionally produced by PF activation plus depolarization. Bath application of NO synthase inhibitor or of myoglobin, a NO trap, prevent LTD induction via PF stimulation, but not that from intracellular uncaged NO, whereas intracellular myoglobin blocked both protocols. NO is therefore an anterograde transmitter in LTD induction. A biochemical requirement for simultaneous NO and elevation of intracellular free Ca2+ would explain why PF activity must coincide with postsynaptic action potentials. | lld:pubmed |
| pubmed-article:7646893 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7646893 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7646893 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7646893 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7646893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7646893 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7646893 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7646893 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7646893 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:7646893 | pubmed:author | pubmed-author:TsienR YRY | lld:pubmed |
| pubmed-article:7646893 | pubmed:author | pubmed-author:Lev-RamVV | lld:pubmed |
| pubmed-article:7646893 | pubmed:author | pubmed-author:KaoJ PJP | lld:pubmed |
| pubmed-article:7646893 | pubmed:author | pubmed-author:MakingsL RLR | lld:pubmed |
| pubmed-article:7646893 | pubmed:author | pubmed-author:KeitzP FPF | lld:pubmed |
| pubmed-article:7646893 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7646893 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:7646893 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7646893 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7646893 | pubmed:pagination | 407-15 | lld:pubmed |
| pubmed-article:7646893 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7646893 | pubmed:meshHeading | pubmed-meshheading:7646893-... | lld:pubmed |
| pubmed-article:7646893 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7646893 | pubmed:articleTitle | Long-term depression in cerebellar Purkinje neurons results from coincidence of nitric oxide and depolarization-induced Ca2+ transients. | lld:pubmed |
| pubmed-article:7646893 | pubmed:affiliation | Department of Pharmacology, University of California, San Diego, La Jolla 92093-0647, USA. | lld:pubmed |
| pubmed-article:7646893 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7646893 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7646893 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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