| pubmed-article:7638179 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C0035435 | lld:lifeskim |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C0004358 | lld:lifeskim |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C0006784 | lld:lifeskim |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C0054534 | lld:lifeskim |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C1999216 | lld:lifeskim |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:7638179 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:7638179 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:7638179 | pubmed:dateCreated | 1995-9-11 | lld:pubmed |
| pubmed-article:7638179 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7638179 | pubmed:abstractText | We identified an autoantibody that reacts with calpastatin [an inhibitor protein of the calcium-dependent neutral protease calpain (EC 3.4.22.17)]. In early immunoblot studies, sera from patients with rheumatoid arthritis (RA) recognized unidentified 60-, 45-, and 75-kDa proteins in HeLa cell extracts. To identify these autoantigens, we used patient sera to clone cDNAs from a lambda gt11 expression library. We isolated clones of four genes that expressed fusion proteins recognized by RA sera. The 1.2-kb cDNA insert (termed RA-6) appeared to encode a polypeptide corresponding to the 60-kDa antigen from HeLa cells, since antibodies bound to the RA-6 fusion protein also reacted with a 60-kDa HeLa protein. The deduced amino acid sequence of the RA-6 cDNA was completely identical with the C-terminal 178 amino acids of human calpastatin except for one amino acid substitution. Patient sera that reacted with the RA-6 also bound pig muscle calpastatin, and a monoclonal antibody to human calpastatin recognized the RA-6 fusion protein, confirming the identity of RA-6 with calpastatin. Moreover, the purified RA-6 fusion protein inhibited the proteolytic activity of calpain, and IgG from a serum containing anti-calpastatin antibodies blocked the calpastatin activity of the RA-6 fusion protein. Immunoblots of the RA-6 product detected autoantibodies to calpastatin in 57% of RA patients; this incidence was significantly higher than that observed in other systemic rheumatic diseases, including systemic lupus erythematosus (27%), polymyositis/dermatomyositis (24%), systemic sclerosis (38%), and overlap syndrome (29%). Thus, anti-calpastatin antibodies are present most frequently in patients with RA and may participate in pathogenic mechanisms of rheumatic diseases. | lld:pubmed |
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| pubmed-article:7638179 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7638179 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7638179 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7638179 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7638179 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7638179 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:SuzukiKK | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:FujiiTT | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:AkizukiMM | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:MatsumuraMM | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:YoshizawaTT | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:NojimaTT | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:MimoriTT | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:TanamiYY | lld:pubmed |
| pubmed-article:7638179 | pubmed:author | pubmed-author:SuganumaKK | lld:pubmed |
| pubmed-article:7638179 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7638179 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:7638179 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7638179 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7638179 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7638179 | pubmed:pagination | 7267-71 | lld:pubmed |
| pubmed-article:7638179 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7638179 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7638179 | pubmed:articleTitle | Autoantibodies to calpastatin (an endogenous inhibitor for calcium-dependent neutral protease, calpain) in systemic rheumatic diseases. | lld:pubmed |
| pubmed-article:7638179 | pubmed:affiliation | Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan. | lld:pubmed |
| pubmed-article:7638179 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7638179 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7638179 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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