| pubmed-article:7636259 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0042769 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0007600 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0027836 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0521390 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0019721 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0041904 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0162493 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0456387 | lld:lifeskim |
| pubmed-article:7636259 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:7636259 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:7636259 | pubmed:dateCreated | 1995-9-8 | lld:pubmed |
| pubmed-article:7636259 | pubmed:abstractText | Adult neurons normally lack the expression of MHC class I molecules, which has implications on virus clearance from the central nervous system. The author previously demonstrated that HLA class I up-regulation in measles virus (MV)-infected glial cells is primarily mediated by IFN-beta. In contrast, this study demonstrates that MV-infection of the neuronal cell lines IMR-32 and CHP-126 fails to up-regulate HLA class I expression, which was associated with an inability of MV to induce IFN-beta in the neuronal cell lines. However, treatment with IFN-beta on coculture of the IMR-32 neuronal cell line with MV-infected glioma cells resulted in the up-regulation of HLA class I on the former, which could be neutralized by anti-IFN-beta Ab. The inability of MV to up-regulate HLA class I expression on the neuronal cell line IMR-32 was not virus specific because similar findings were observed with mumps virus or stimulation with the synthetic dsRNA polyinosinic polycytidylic acid (PIPC). Induction of IFN-beta gene expression by virus requires binding of NF-kappa B to the positive regulatory domain II element of the IFN-beta promoter. Our studies indicate that MV, TNF-alpha, or PIPC induces NF-kappa B (p50 and p65 subunits) binding to positive regulatory domain II in the glioma cell line. In contrast, such activity was induced by TNF-alpha but not MV or PIPC in the neuronal cell line IMR-32. This indicated that HLA class I expression is differentially regulated in glial and neuronal cell lines in response to MV, which correlates with differential binding of NF-kappa B to the IFN-beta promoter and induction of IFN-beta gene expression. | lld:pubmed |
| pubmed-article:7636259 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7636259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7636259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7636259 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7636259 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7636259 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:7636259 | pubmed:author | pubmed-author:SwovelandP... | lld:pubmed |
| pubmed-article:7636259 | pubmed:author | pubmed-author:XiaQQ | lld:pubmed |
| pubmed-article:7636259 | pubmed:author | pubmed-author:FishB JBJ | lld:pubmed |
| pubmed-article:7636259 | pubmed:author | pubmed-author:Dhib-JalbutS... | lld:pubmed |
| pubmed-article:7636259 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7636259 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7636259 | pubmed:volume | 155 | lld:pubmed |
| pubmed-article:7636259 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7636259 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7636259 | pubmed:pagination | 2096-108 | lld:pubmed |
| pubmed-article:7636259 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
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| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:meshHeading | pubmed-meshheading:7636259-... | lld:pubmed |
| pubmed-article:7636259 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7636259 | pubmed:articleTitle | Differential up-regulation of HLA class I molecules on neuronal and glial cell lines by virus infection correlates with differential induction of IFN-beta. | lld:pubmed |
| pubmed-article:7636259 | pubmed:affiliation | Department of Neurology, University of Maryland at Baltimore 21201, USA. | lld:pubmed |
| pubmed-article:7636259 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7636259 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7636259 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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