| pubmed-article:7635279 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C0019425 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C0026882 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C1413190 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C1419240 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C1419243 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C1422405 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C1422515 | lld:lifeskim |
| pubmed-article:7635279 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:7635279 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7635279 | pubmed:dateCreated | 1995-9-13 | lld:pubmed |
| pubmed-article:7635279 | pubmed:abstractText | The RAD52 gene of Saccharomyces cerevisiae is involved both in the recombinational repair of DNA damage and in mitotic and meiotic recombination. A new allele of rad52 has been isolated that has unusual properties. Unlike other alleles of rad52, this allele (rad52-20) is partially suppressed by an srs2 deletion; srs2 mutations normally act to suppress only rad6 and rad18 mutations. In addition, although haploid rad52-20 strains are very X-ray sensitive, diploids homozygous for this allele are only slightly X-ray sensitive and undergo normal meiosis and meiotic recombination. Because rad52-20 diploids homozygous for mating type are very X-ray sensitive, mating-type heterozygosity is acting to suppress rad52-20. Mating-type heterozygosity suppresses this allele even in haploids, because sir mutations, which result in expression of the normally silent mating-type cassettes, were identified among the extragenic revertants of rad52-20. A new allele of srs2 and alleles of the transcriptional regulatory genes ccr4 and caf1 were among the other extragenic revertants of rad52-20. Because other researchers have shown that the RAD51 and RAD52 proteins interact, RAD51 on a high copy number plasmid was tested and found to suppress the rad52-20 allele, but RAD54, 55 and 57 did not suppress. The RAD51 plasmid did not suppress rad52-1. The rad52-20 allele may encode a protein that has low affinity binding to the RAD51 protein. To test whether the selected revertants suppressed rad52-20 by elevating the expression of RAD51, an integrated RAD51-lacZ fusion was genetically crossed into each revertant. Because none of the revertants increased the level of RAD51-lacZ, the revertants must exert their effect by one or more mechanisms that are not mediated by RAD51. | lld:pubmed |
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| pubmed-article:7635279 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7635279 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7635279 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7635279 | pubmed:month | May | lld:pubmed |
| pubmed-article:7635279 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:7635279 | pubmed:author | pubmed-author:SchildDD | lld:pubmed |
| pubmed-article:7635279 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7635279 | pubmed:volume | 140 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | CCR4 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | SIR2 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | RAD51 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | SIR1 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | SIR3 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | RAD54 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | RAD52 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | RAD57 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | RAD55 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | SIR4 | lld:pubmed |
| pubmed-article:7635279 | pubmed:geneSymbol | MAT&agr;2 | lld:pubmed |
