| pubmed-article:7615825 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C1335073 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0084821 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0085201 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C0013879 | lld:lifeskim |
| pubmed-article:7615825 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:7615825 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7615825 | pubmed:dateCreated | 1995-8-24 | lld:pubmed |
| pubmed-article:7615825 | pubmed:abstractText | We have used apolipoprotein genes to investigate the signal transduction mechanisms involved in the control of intestinal specific gene expression. The human apoAI, apoCIII, and apoAIV genes are tandemly organized within a 15-kb DNA segment and are expressed predominantly in the liver and intestine. Transient transfection of various human apoAI gene plasmid constructs into human hepatoma (HepG2) and colon carcinoma (Caco-2) cells showed that apoAI gene transcription is under the control of two separate and distinct cell-specific promoters. The region between nucleotides -192 and -41 is essential for expression in HepG2 cells, whereas the region from -595 to -192 is essential for expression in Caco-2 cells. A third 0.6 kb DNA fragment in the apoCIII gene promoter region, approximately 5 kb down-stream from the human apoAI gene, enhances transcription mediated by either of these two tissue-specific apoAI promoters. In Caco-2 cells, expression of the apoAI gene and activation by the distal enhancer required the presence of a nuclear hormone receptor response element (NHRRE) located in the -214 to -192 apoAI promoter region. Overexpression of the orphan receptor hepatocyte nuclear factor 4 (HNF-4), which binds to the NHRRE, dramatically stimulates apoAI gene expression in Caco-2 cells but not in HepG2 cells. Maximal stimulation of transcription by HNF-4 in Caco-2 cells required the presence of both the intestinal specific promoter, the NHRRE, and distal enhancer elements. Transactivation by HNF-4 thus appears to result from functional synergy between the NHRRE binding HNF-4 and distal DNA elements containing intestinal-specific DNA binding activities. The apoAI gene provides a model system to define the mechanism(s) governing intestinal cell specific gene regulation and the role of nuclear hormone receptors in the establishment and regulation of enterocytic gene transcription. | lld:pubmed |
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| pubmed-article:7615825 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7615825 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7615825 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:7615825 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7615825 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7615825 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:7615825 | pubmed:author | pubmed-author:KarathanasisS... | lld:pubmed |
| pubmed-article:7615825 | pubmed:author | pubmed-author:GinsburgG SGS | lld:pubmed |
| pubmed-article:7615825 | pubmed:author | pubmed-author:OzerJJ | lld:pubmed |
| pubmed-article:7615825 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7615825 | pubmed:volume | 96 | lld:pubmed |
| pubmed-article:7615825 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7615825 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7615825 | pubmed:pagination | 528-38 | lld:pubmed |
| pubmed-article:7615825 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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