| pubmed-article:7609783 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7609783 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:7609783 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7609783 | lifeskim:mentions | umls-concept:C2334101 | lld:lifeskim |
| pubmed-article:7609783 | lifeskim:mentions | umls-concept:C0001443 | lld:lifeskim |
| pubmed-article:7609783 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:7609783 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7609783 | pubmed:dateCreated | 1995-8-17 | lld:pubmed |
| pubmed-article:7609783 | pubmed:abstractText | The effects of adenosine on the L-type Ca2+ current (Ica) were studied in human atrial myocytes using the whole-cell voltage clamp technique. Ica was recorded under physiological calcium concentrations (1.8 mmol/l) at 37 degrees C. Under these conditions the current density of basal Ica averaged 4.0 pA/pF. Isoprenaline (1 mumol/l) increased basal Ica to 249.7%. Adenosine (100 mumol/l) in the presence of isoprenaline (1 mumol/l) decreased Ica from the level obtained with isoprenaline to 87.5% of basal Ica. Adenosine (0.1 to 100 mumol/l) also reduced basal Ica, maximally to 64.5% of control. Activation and inactivation parameters of basal Ica were not significantly different between adenosine (100 mumol/l) and control recordings. Our results show that adenosine affects both basal and isoprenaline stimulated Ica in human atrial myocytes. Although a considerable decrease of basal Ica was seen, we conclude that the action of adenosine on L-type Ca2+ current in human atrial myocytes is mainly antiadrenergic. Both effects may contribute to the antiarrhythmic properties of adenosine. | lld:pubmed |
| pubmed-article:7609783 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7609783 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7609783 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7609783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7609783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7609783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7609783 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7609783 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7609783 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7609783 | pubmed:issn | 0028-1298 | lld:pubmed |
| pubmed-article:7609783 | pubmed:author | pubmed-author:KoidaMM | lld:pubmed |
| pubmed-article:7609783 | pubmed:author | pubmed-author:SchafferPP | lld:pubmed |
| pubmed-article:7609783 | pubmed:author | pubmed-author:RiglerBB | lld:pubmed |
| pubmed-article:7609783 | pubmed:author | pubmed-author:PelzmannBB | lld:pubmed |
| pubmed-article:7609783 | pubmed:author | pubmed-author:MächlerHH | lld:pubmed |
| pubmed-article:7609783 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7609783 | pubmed:volume | 351 | lld:pubmed |
| pubmed-article:7609783 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7609783 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7609783 | pubmed:pagination | 293-7 | lld:pubmed |
| pubmed-article:7609783 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:meshHeading | pubmed-meshheading:7609783-... | lld:pubmed |
| pubmed-article:7609783 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7609783 | pubmed:articleTitle | Adenosine inhibits the L-type calcium current in human atrial myocytes. | lld:pubmed |
| pubmed-article:7609783 | pubmed:affiliation | Institut für Medizinische Physik und Biophysik, Universität Graz, Austria. | lld:pubmed |
| pubmed-article:7609783 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7609783 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7609783 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7609783 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7609783 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7609783 | lld:pubmed |
