| pubmed-article:7606338 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0205054 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0015684 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C1519020 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C1979928 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C1554963 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C1449704 | lld:lifeskim |
| pubmed-article:7606338 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:7606338 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:7606338 | pubmed:dateCreated | 1995-8-17 | lld:pubmed |
| pubmed-article:7606338 | pubmed:abstractText | 1. The time-course of the effect of clofibrate (CFB), bezafibrate (BFB) and gemfibrozil (GFB) on lipid plasma levels and palmitoyl-, palmitoleoyl- and gamma-linolenoyl-CoA elongase, delta-9, delta-6 and delta-5 desaturase activities, and microsomal electron transport chains, as well as the correlation with the peroxisomal proliferation phenomenon have been studied in male Sprague-Dawley rats. 2. As reported in our previous work, the three drugs behave as peroxisomal proliferators (the order of potency was BFB > CFB > or = GFB) and induced a clear reduction in both plasma cholesterol and triglyceride levels. 3. Palmitoyl-CoA elongation activity was increased by the three drugs (BFB = GFB > CFB), whereas palmitoleoyl-CoA elongation activity was only enhanced by GFB. Elongation activity was not modified by fibrates when gamma-linolenoyl-CoA was used as substrate. These results are in accordance with the existence of three different elongation systems for saturated, mono- and polyunsaturated fatty acids. 4. delta-9, delta-6 and delta-5 desaturase activities were increased by the three fibrates, with an order of potency BFB > CFB = GFB for delta-9 and delta-5, and GFB > BFB = CFB for delta-6. 5. Of the enzyme activities integrated in the microsomal electron transport chains, NADH cytochrome b5 reductase was not affected by fibrate treatment, NADPH cytochrome c reductase activity was enhanced (BFB = GFB > CFB), whereas NADH cytochrome c reductase activity was reduced by CFB and BFB. 6. The increase in Delta-9 and Delta-5 desaturase activities was highly dependent on the peroxisomal proliferation phenomena, whereas the increase in Delta-6 desaturase activity and the decrease in NADH cytochromec reductase was mainly independent. The modifications of palmitoyl-CoA elongase and NADPH cytochrome c reductase activities, as well as plasma lipid levels, were partially correlated with peroxisomal beta-oxidation, but the r2 values obtained point to the existence of additional independent mechanisms.7. As man is assumed to be a species refractory to peroxisomal proliferation, only those fibrate effectsnot absolutely related to this phenomenon are expected to appear after fibrate therapy. | lld:pubmed |
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| pubmed-article:7606338 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7606338 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7606338 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7606338 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7606338 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7606338 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7606338 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:FerrandoRR | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:VázquezMM | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:AdzetTT | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:MerlotLL | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:SánchezR MRM | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:LagunaJ CJC | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:AlegretMM | lld:pubmed |
| pubmed-article:7606338 | pubmed:author | pubmed-author:CerquedaEE | lld:pubmed |
| pubmed-article:7606338 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7606338 | pubmed:volume | 114 | lld:pubmed |
| pubmed-article:7606338 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7606338 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7606338 | pubmed:pagination | 1351-8 | lld:pubmed |
| pubmed-article:7606338 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:7606338 | pubmed:meshHeading | pubmed-meshheading:7606338-... | lld:pubmed |
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| pubmed-article:7606338 | pubmed:meshHeading | pubmed-meshheading:7606338-... | lld:pubmed |
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| pubmed-article:7606338 | pubmed:meshHeading | pubmed-meshheading:7606338-... | lld:pubmed |
| pubmed-article:7606338 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7606338 | pubmed:articleTitle | Selective modification of rat hepatic microsomal fatty acid chain elongation and desaturation by fibrates: relationship with peroxisome proliferation. | lld:pubmed |
| pubmed-article:7606338 | pubmed:affiliation | Dept. Farmacología y Química Terapeutica, Facultad de Farmacia, Núcleo Universitario de Pedralbes, Barcelona, Spain. | lld:pubmed |
| pubmed-article:7606338 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7606338 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
