| pubmed-article:7605638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7605638 | lifeskim:mentions | umls-concept:C0687735 | lld:lifeskim |
| pubmed-article:7605638 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:7605638 | lifeskim:mentions | umls-concept:C0598352 | lld:lifeskim |
| pubmed-article:7605638 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:7605638 | lifeskim:mentions | umls-concept:C0183210 | lld:lifeskim |
| pubmed-article:7605638 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:7605638 | pubmed:dateCreated | 1995-8-11 | lld:pubmed |
| pubmed-article:7605638 | pubmed:abstractText | The S4 segment comprises part of the voltage sensor in Shaker K+ channels. We have used a strategy similar to intragenic suppression, but without a genetic selection, to identify electrostatic interactions of the S4 segment that may be important in the mechanism of voltage-dependent activation. The S4 neutralization mutations K374Q and R377Q block maturation of the protein, suggesting that they prevent proper folding. K374Q is specifically and efficiently rescued by the second site mutations E293Q and D316N, located in putative transmembrane segments S2 and S3, respectively. These results suggest that K374, E293, and D316 form a network of strong, local, electrostatic interactions that stabilize the structure of the channel. Some other double mutant combinations result in inefficient suppression, identifying weak, presumably long-range electrostatic interactions. A simple structural hypothesis is proposed to account for the effects of the rescued double mutant combinations on the relative stabilities of open and closed channel conformations. | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7605638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7605638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7605638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7605638 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7605638 | pubmed:issn | 0896-6273 | lld:pubmed |
| pubmed-article:7605638 | pubmed:author | pubmed-author:HuangYY | lld:pubmed |
| pubmed-article:7605638 | pubmed:author | pubmed-author:PapazianD MDM | lld:pubmed |
| pubmed-article:7605638 | pubmed:author | pubmed-author:ShaoX MXM | lld:pubmed |
| pubmed-article:7605638 | pubmed:author | pubmed-author:SeohS ASA | lld:pubmed |
| pubmed-article:7605638 | pubmed:author | pubmed-author:MockA FAF | lld:pubmed |
| pubmed-article:7605638 | pubmed:author | pubmed-author:WainstockD... | lld:pubmed |
| pubmed-article:7605638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7605638 | pubmed:volume | 14 | lld:pubmed |
| pubmed-article:7605638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7605638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7605638 | pubmed:pagination | 1293-301 | lld:pubmed |
| pubmed-article:7605638 | pubmed:dateRevised | 2010-10-4 | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:meshHeading | pubmed-meshheading:7605638-... | lld:pubmed |
| pubmed-article:7605638 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7605638 | pubmed:articleTitle | Electrostatic interactions of S4 voltage sensor in Shaker K+ channel. | lld:pubmed |
| pubmed-article:7605638 | pubmed:affiliation | Department of Physiology, School of Medicine, University of California, Los Angeles 90024, USA. | lld:pubmed |
| pubmed-article:7605638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7605638 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7605638 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:32780 | entrezgene:pubmed | pubmed-article:7605638 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7605638 | lld:pubmed |
