| pubmed-article:7595148 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0020663 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C1533685 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0003741 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0120348 | lld:lifeskim |
| pubmed-article:7595148 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:7595148 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7595148 | pubmed:dateCreated | 1995-11-27 | lld:pubmed |
| pubmed-article:7595148 | pubmed:abstractText | In the rat, the synthetic GH secretagogue GH-releasing peptide (GHRP-6) acts centrally to activate a subpopulation of arcuate neurones as reflected by increased electrical activation and by the detection of Fos protein in cell nuclei. Since GHRP-6 also induces GH secretion via a direct action on the pituitary, we set out to determine whether the central actions of GHRP-6 are mediated by GH itself. First, we demonstrated that peripherally administered GHRP-6 induces Fos expression in the arcuate nucleus of GH-deficient animals (dw/dw rats and lit/lit mice). Secondly, in dw/dw rats, neither intracerebroventricular injection of 15 micrograms recombinant bovine GH nor 1 microgram recombinant human IGF-I resulted in an increase in the number of cells expressing Fos protein in the arcuate nucleus (or in any other hypothalamic structure studied). These results support our hypothesis that GHRP-6 has a central site and mechanism of action and provide evidence to suggest that the activation of arcuate neurones by GHRP-6 is not mediated by a central action of GH or IGF-I. Furthermore, since the lit/lit mouse pituitary does not release GH following GHRP-6 administration, our finding that the central actions of GHRP-6 remain intact in these animals suggests the possible existence of two subpopulations of putative GHRP-6 receptors. | lld:pubmed |
| pubmed-article:7595148 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7595148 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7595148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7595148 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7595148 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:7595148 | pubmed:issn | 0022-0795 | lld:pubmed |
| pubmed-article:7595148 | pubmed:author | pubmed-author:LenkCC | lld:pubmed |
| pubmed-article:7595148 | pubmed:author | pubmed-author:DicksonS LSL | lld:pubmed |
| pubmed-article:7595148 | pubmed:author | pubmed-author:Doutrelant-Vi... | lld:pubmed |
| pubmed-article:7595148 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7595148 | pubmed:volume | 146 | lld:pubmed |
| pubmed-article:7595148 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7595148 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7595148 | pubmed:pagination | 519-26 | lld:pubmed |
| pubmed-article:7595148 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:meshHeading | pubmed-meshheading:7595148-... | lld:pubmed |
| pubmed-article:7595148 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7595148 | pubmed:articleTitle | GH-deficient dw/dw rats and lit/lit mice show increased Fos expression in the hypothalamic arcuate nucleus following systemic injection of GH-releasing peptide-6. | lld:pubmed |
| pubmed-article:7595148 | pubmed:affiliation | Laboratory of Neuroendocrinology, Babraham Institute, Cambridge, UK. | lld:pubmed |
| pubmed-article:7595148 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7595148 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:14281 | entrezgene:pubmed | pubmed-article:7595148 | lld:entrezgene |
| entrez-gene:14602 | entrezgene:pubmed | pubmed-article:7595148 | lld:entrezgene |
| entrez-gene:18736 | entrezgene:pubmed | pubmed-article:7595148 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7595148 | lld:pubmed |
