| pubmed-article:7554481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C0019693 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C0330390 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C0019764 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C0242656 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C1413221 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C0175630 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:7554481 | lifeskim:mentions | umls-concept:C2348205 | lld:lifeskim |
| pubmed-article:7554481 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7554481 | pubmed:dateCreated | 1995-10-25 | lld:pubmed |
| pubmed-article:7554481 | pubmed:abstractText | Three-color automated flow cytometry was carried out on peripheral blood CD4+ and CD8+ T-lymphocytes of 42 HIV-positive patients using tri-color anti-CD4 or anti-CD8, phycoerythrin-anti-CD38, and fluorescein-anti-HLA-DR, mAbs to elucidate further the T-cell activation hypothesis recently proposed to explain CD4+ T-cell abnormalities observed during HIV infection. CD4+ CD38+ T-cells constituted the major part of circulating CD4+ T-cells in HIV-infected patients and their HLA-DR molecule positivity increased as their disease progressed. The level of CD38 and HLA-DR expression on CD4+ T-cells was positively correlated to that of CD8+ T-cells and to the level of beta 2-microglobulin. Next, to determine whether CD38 expression was associated with a selective expansion or deletion of V beta gene-defined subsets, we compared the V beta gene frequencies between CD38+ and CD38- T-cells from HIV-infected CDC stage II patients using 13 mAbs specific to V beta families. While selective expansion of certain V beta families was observed in CD4+ and CD8+ T-cells the T-cell receptor V beta subset distribution was similar among CD38+ and CD38-, CD4+ and CD8+ T-cells, suggesting that CD38+ expression was either independent of an HIV-encoded antigen-driven process or rather indicative of T-cell immaturity. It is proposed that the phenotype of circulating CD4+ and CD8+ T-cells of HIV-infected patients is a feature of two different mechanisms: (i) an in vitro activation state responsible for increased DR expression and selective expansion of V beta gene-defined subsets, and (ii) T-cell immaturity due to an increased turnover of these cells and accounting for increased CD38 expression. | lld:pubmed |
| pubmed-article:7554481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7554481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7554481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7554481 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7554481 | pubmed:issn | 0090-1229 | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:GilbertDD | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:TropDD | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:HumbertGG | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:MichelYY | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:Borsa-LebasFF | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:Jouen-BeadesF... | lld:pubmed |
| pubmed-article:7554481 | pubmed:author | pubmed-author:RamzaouiSS | lld:pubmed |
| pubmed-article:7554481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7554481 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:7554481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7554481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7554481 | pubmed:pagination | 33-41 | lld:pubmed |
| pubmed-article:7554481 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:7554481 | pubmed:meshHeading | pubmed-meshheading:7554481-... | lld:pubmed |
| pubmed-article:7554481 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7554481 | pubmed:articleTitle | During HIV infection, CD4+ CD38+ T-cells are the predominant circulating CD4+ subset whose HLA-DR positivity increases with disease progression and whose V beta repertoire is similar to that of CD4+ CD38- T-cells. | lld:pubmed |
| pubmed-article:7554481 | pubmed:affiliation | Groupe de Recherche en Immunopathologie, Institut Fédératif de Recherche Multidisciplinaire sur les Peptides, France. | lld:pubmed |
| pubmed-article:7554481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7554481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7554481 | lld:pubmed |
