| pubmed-article:7540704 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C2598134 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0006826 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0086543 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0012155 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0023317 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0009325 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0039259 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0015895 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0017817 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0017725 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0178487 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C1286235 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0449258 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0033105 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0030011 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C1879985 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C1556156 | lld:lifeskim |
| pubmed-article:7540704 | lifeskim:mentions | umls-concept:C0443288 | lld:lifeskim |
| pubmed-article:7540704 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7540704 | pubmed:dateCreated | 1995-7-27 | lld:pubmed |
| pubmed-article:7540704 | pubmed:abstractText | The Emory mouse is the best model for age-related cataract. In this work we compare the effects of feeding a control diet (C) with a diet restricted (R) by 40% relative to C animals. In the R animals, median lifespan was extended by 40%. The proportion of R mice with advanced cataract was lower than C mice as early as 5 months of age. The mean grade of cataract was lower in R animals, beginning at 11 months and continuing until the end of the study. Ascorbate levels in R plasma and liver were 41-56% of C animals. There was no difference between diet groups with respect to lens ascorbate. Aging was associated with a decrease in ascorbate in lenses and kidneys in C and R mice. By 22 months, R animals had 48% higher liver glutathione levels than C mice. Liver glutathione levels were maximal at 12 months. Plasma glucose levels were > 27% lower in R animals at 6.5 and 22 months, and there was a 14% increase in glucose levels upon aging for both diet groups. In R mice, glycohemoglobin levels were 51% lower and tail collagen breaktime was decreased by 40%, even in younger animals. Collagen breaktime increased > 360% upon aging for both diet groups. Rates of production of urinary oxo8dG and oxo8G were higher in R animals compared with C animals, and increased upon aging. C animals exhibited more cancer and dermatological lesions, but less tail tip necrosis and inflamed genitals than R mice. These data allow evaluation of several theories of aging. | lld:pubmed |
| pubmed-article:7540704 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7540704 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7540704 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7540704 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7540704 | pubmed:issn | 0047-6374 | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:SmithDD | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:TaylorAA | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:NGLL | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:DallalG EGE | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:Jahngen-Hodge... | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:LaxmanEE | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:LipmanR DRD | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:PalmerVV | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:ShepardDD | lld:pubmed |
| pubmed-article:7540704 | pubmed:author | pubmed-author:PadhyeNN | lld:pubmed |
| pubmed-article:7540704 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7540704 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:7540704 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:7540704 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7540704 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7540704 | pubmed:pagination | 33-57 | lld:pubmed |
| pubmed-article:7540704 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:7540704 | pubmed:meshHeading | pubmed-meshheading:7540704-... | lld:pubmed |
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| pubmed-article:7540704 | pubmed:meshHeading | pubmed-meshheading:7540704-... | lld:pubmed |
| pubmed-article:7540704 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7540704 | pubmed:articleTitle | Dietary calorie restriction in the Emory mouse: effects on lifespan, eye lens cataract prevalence and progression, levels of ascorbate, glutathione, glucose, and glycohemoglobin, tail collagen breaktime, DNA and RNA oxidation, skin integrity, fecundity, and cancer. | lld:pubmed |
| pubmed-article:7540704 | pubmed:affiliation | Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA. | lld:pubmed |
| pubmed-article:7540704 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7540704 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7540704 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7540704 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| entrez-gene:104017 | entrezgene:pubmed | pubmed-article:7540704 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7540704 | lld:pubmed |
