| pubmed-article:7537264 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0054450 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0178719 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0042219 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0018437 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0019868 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C0392337 | lld:lifeskim |
| pubmed-article:7537264 | lifeskim:mentions | umls-concept:C2700289 | lld:lifeskim |
| pubmed-article:7537264 | pubmed:issue | 17 | lld:pubmed |
| pubmed-article:7537264 | pubmed:dateCreated | 1995-6-1 | lld:pubmed |
| pubmed-article:7537264 | pubmed:abstractText | Saccharomyces cerevisiae VMA genes, encoding essential components for the expression of vacuolar membrane H(+)-ATPase activity, are involved in intracellular ionic homeostasis and vacuolar biogenesis. We report here that the immunosuppressants FK506 and cyclosporin A cause general growth inhibition of the vma3 mutant. Upon addition of the drugs, the mutant grew neither in the presence of more than 5 mM Ca2+ nor above pH 6.0. The action of the immunosuppressants is dependent on their binding proteins and ascribable to inhibition of calcineurin activity; a mutation of a calcineurin subunit (cnb1) shows synthetic lethal interaction with the vma mutation. The addition of FK506 decreases the cytosolic free concentration of Ca2+ in the vma3 mutant cells. Consequently, FK506 induces an 8.9-fold elevation of a nonexchangeable Ca2+ pool. These results suggest that calcineurin controls calcium homeostasis by repression of Ca2+ flux into a cellular compartment(s) and that the vacuolar H(+)-ATPase is essential for cell growth cooperating with calcineurin to regulate the cytosolic free concentration of Ca2+. | lld:pubmed |
| pubmed-article:7537264 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7537264 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7537264 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7537264 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7537264 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7537264 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:7537264 | pubmed:author | pubmed-author:HasegawaAA | lld:pubmed |
| pubmed-article:7537264 | pubmed:author | pubmed-author:AnrakuYY | lld:pubmed |
| pubmed-article:7537264 | pubmed:author | pubmed-author:IidaHH | lld:pubmed |
| pubmed-article:7537264 | pubmed:author | pubmed-author:LyleL RLR | lld:pubmed |
| pubmed-article:7537264 | pubmed:author | pubmed-author:TanidaII | lld:pubmed |
| pubmed-article:7537264 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7537264 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:7537264 | pubmed:volume | 270 | lld:pubmed |
| pubmed-article:7537264 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7537264 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7537264 | pubmed:pagination | 10113-9 | lld:pubmed |
| pubmed-article:7537264 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:7537264 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7537264 | pubmed:articleTitle | Cooperation of calcineurin and vacuolar H(+)-ATPase in intracellular Ca2+ homeostasis of yeast cells. | lld:pubmed |
| pubmed-article:7537264 | pubmed:affiliation | Department of Plant Sciences, Graduate School of Science, University of Tokyo, Japan. | lld:pubmed |
| pubmed-article:7537264 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7537264 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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