| pubmed-article:7536936 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0043292 | lld:lifeskim |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0205177 | lld:lifeskim |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0025723 | lld:lifeskim |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0018591 | lld:lifeskim |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0600261 | lld:lifeskim |
| pubmed-article:7536936 | lifeskim:mentions | umls-concept:C0205349 | lld:lifeskim |
| pubmed-article:7536936 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7536936 | pubmed:dateCreated | 1995-5-25 | lld:pubmed |
| pubmed-article:7536936 | pubmed:abstractText | During early mammalian embryogenesis, one of the two X chromosomes in somatic cells of the female becomes inactivated through a process that is thought to depend on a unique initiator region, the X-chromosome inactivation center (Xic). The recently characterized Xist sequence (X-inactive-specific transcript) is thought to be a possible candidate for Xic. In mice a further genetic element, the X chromosome-controlling element (Xce), is also known to influence the choice of which of the two X chromosomes is inactivated. We report that a region of the mouse X chromosome lying 15 kb distal to Xist contains several sites that show hypermethylation specifically associated with the active X chromosome. Analysis of this region in various Xce strains has revealed a correlation between the strength of the Xce allele carried and the methylation status of this region. We propose that such a region could be involved in the initial stages of the inactivation process and in particular in the choice of which of the two X chromosomes present in a female cell will be inactivated. | lld:pubmed |
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| pubmed-article:7536936 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7536936 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7536936 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7536936 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7536936 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7536936 | pubmed:author | pubmed-author:AvnerPP | lld:pubmed |
| pubmed-article:7536936 | pubmed:author | pubmed-author:HeardEE | lld:pubmed |
| pubmed-article:7536936 | pubmed:author | pubmed-author:CourtieuGG | lld:pubmed |
| pubmed-article:7536936 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7536936 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:7536936 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7536936 | pubmed:geneSymbol | Xist | lld:pubmed |
| pubmed-article:7536936 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7536936 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7536936 | pubmed:pagination | 3531-5 | lld:pubmed |
| pubmed-article:7536936 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7536936 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7536936 | pubmed:articleTitle | Xce haplotypes show modified methylation in a region of the active X chromosome lying 3' to Xist. | lld:pubmed |
| pubmed-article:7536936 | pubmed:affiliation | Unité de Génétique Moléculaire Murine, Institut Pasteur, Paris, France. | lld:pubmed |
| pubmed-article:7536936 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7536936 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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