| pubmed-article:7531109 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0028429 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C2607914 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0019588 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0030685 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C1948023 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0680255 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C1283071 | lld:lifeskim |
| pubmed-article:7531109 | lifeskim:mentions | umls-concept:C1963578 | lld:lifeskim |
| pubmed-article:7531109 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:7531109 | pubmed:dateCreated | 1995-3-8 | lld:pubmed |
| pubmed-article:7531109 | pubmed:abstractText | The effects of nasal administration of increasing doses of exogenous substance P have been studied in patients with allergic rhinitis treated with placebo or with the H1 antagonist cetirizine (10 mg twice daily for 3 days). Responses to substance P were assessed by posterior rhinomanometry (measuring nasal airway resistance) and by measure of histamine, protein and albumin production and cell recovery in nasal lavage fluids before and after challenge. Substance P induced a dose-dependent increase in nasal airway resistance which was similar after treatment with either cetirizine or placebo (maximal increase in nasal airway resistance was 4.2-fold greater than the baseline with the placebo and 4.7-fold greater than the baseline with cetirizine). No histamine release was observed. Similar increases in protein and albumin production were observed after stimulation with substance P along with the placebo (protein: from 0.35 +/- 0.11 to 3.31 +/- 0.62 mg and albumin: from 0.09 +/- 0.04 to 2.08 +/- 0.39 mg) and when combined with cetirizine treatment (proteins: from 0.42 +/- 0.09 to 3.62 +/- 0.77 and albumin: from 0.17 +/- 0.04 to 2.19 +/- 0.51 mg). After stimulation with substance P, percentages of neutrophils recovered in nasal fluids increased from 26.2 +/- 11.5 to 54.5 +/- 9.5 with the placebo and from 35.5 +/- 11.0 to 53.6 +/- 9.5 with cetirizine. Eosinophils were inconsistently found after substance P stimulation during both treatments. In conclusion, nasal response to substance P is not modified by cetirizine which suggests that the effect of substance P is not secondary to histamine release in the nose in man. | lld:pubmed |
| pubmed-article:7531109 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531109 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7531109 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531109 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7531109 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531109 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7531109 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7531109 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:7531109 | pubmed:issn | 0954-7894 | lld:pubmed |
| pubmed-article:7531109 | pubmed:author | pubmed-author:LacroniqueJJ | lld:pubmed |
| pubmed-article:7531109 | pubmed:author | pubmed-author:BuvryAA | lld:pubmed |
| pubmed-article:7531109 | pubmed:author | pubmed-author:BraunsteinGG | lld:pubmed |
| pubmed-article:7531109 | pubmed:author | pubmed-author:FrossardNN | lld:pubmed |
| pubmed-article:7531109 | pubmed:author | pubmed-author:DesjardinsNN | lld:pubmed |
| pubmed-article:7531109 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7531109 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:7531109 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7531109 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7531109 | pubmed:pagination | 922-9 | lld:pubmed |
| pubmed-article:7531109 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
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| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:meshHeading | pubmed-meshheading:7531109-... | lld:pubmed |
| pubmed-article:7531109 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7531109 | pubmed:articleTitle | Do nasal mast cells release histamine on stimulation with substance P in allergic rhinitis? | lld:pubmed |
| pubmed-article:7531109 | pubmed:affiliation | Laboratoire de physiologie respiratoire, UFR Cochin-Port-Royal, Paris, France. | lld:pubmed |
| pubmed-article:7531109 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7531109 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:7531109 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:7531109 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:7531109 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7531109 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7531109 | lld:pubmed |
