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pubmed-article:7524822pubmed:abstractTextThe molecular distribution of insulin-like growth factor I (IGF-I) and IGF-II among the IGF binding proteins (IGFBPs) was studied before and during IGF-I therapy in Ecuadorean adults with growth hormone receptor deficiency (GHRD). Of the total circulating IGF-I and IGF-II, 70% was carried by the 150 kDa complex in normal subjects, while in patients with GHRD, 50% of serum IGF-I, but only 30-35% of serum IGF-II, was measured within the 150 kDa IGFBP-3 region. Administration of IGF-I altered the concentration of IGF-I and IGF-II, although the percentage of total IGF measured within each IGFBP region was not affected, as the increase in IGF-I and the decrease in IGF-II were proportional. Similarly, serum concentrations of IGFBP-3 and the acid-labile subunit, measured by radioimmunoassay, were unaltered. Thus, administration of IGF-I to patients with GHRD was unable to correct the aberrant distribution of IGFs among the IGFBPs.lld:pubmed
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pubmed-article:7524822pubmed:dateRevised2008-5-12lld:pubmed
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pubmed-article:7524822pubmed:articleTitleEffects of insulin-like growth factor I treatment on the molecular distribution of insulin-like growth factors among different binding proteins.lld:pubmed
pubmed-article:7524822pubmed:affiliationDepartment of Pediatrics, Stanford University School of Medicine, California.lld:pubmed
pubmed-article:7524822pubmed:publicationTypeJournal Articlelld:pubmed