| pubmed-article:7486903 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7486903 | lifeskim:mentions | umls-concept:C0319899 | lld:lifeskim |
| pubmed-article:7486903 | lifeskim:mentions | umls-concept:C1512072 | lld:lifeskim |
| pubmed-article:7486903 | lifeskim:mentions | umls-concept:C0016277 | lld:lifeskim |
| pubmed-article:7486903 | lifeskim:mentions | umls-concept:C0678226 | lld:lifeskim |
| pubmed-article:7486903 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:7486903 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:7486903 | pubmed:dateCreated | 1995-12-26 | lld:pubmed |
| pubmed-article:7486903 | pubmed:abstractText | We report on the mechanism of fluconazole resistance in Candida glabrata from a case of infection in which pre- and posttreatment isolates were available for comparison. The resistant, posttreatment isolate was cross-resistant to ketoconazole and itraconazole, in common with other azole-resistant yeasts. Resistance was due to reduced levels of accumulation of [3H]fluconazole rather than to changes at the level of ergosterol biosynthesis. Studies with metabolic or respiratory inhibitors showed that this phenomenon was a consequence of energy-dependent drug efflux, as opposed to a barrier to influx. Since energy-dependent efflux is a characteristic of multidrug resistance in bacteria, yeasts, and mammalian cells, we investigated the possibility that fluconazole resistance is mediated by a multidrug resistance-type mechanism. Benomyl, a substrate for the Candida albicans multidrug resistance protein, showed competition with fluconazole for efflux from resistance C. glabrata isolates, consistent with a common efflux mechanism for these compounds. By contrast, other standard substrates or inhibitors of multidrug resistance proteins had no effect on fluconazole efflux. In conclusion, we have identified energy-dependent efflux of fluconazole, possibly via a multidrug resistance-type transporter, as the mechanism of resistance to fluconazole in C. glabrata. | lld:pubmed |
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| pubmed-article:7486903 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7486903 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7486903 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7486903 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7486903 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7486903 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:7486903 | pubmed:author | pubmed-author:HitchcockC... | lld:pubmed |
| pubmed-article:7486903 | pubmed:author | pubmed-author:ParkinsonTT | lld:pubmed |
| pubmed-article:7486903 | pubmed:author | pubmed-author:FalconerD JDJ | lld:pubmed |
| pubmed-article:7486903 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7486903 | pubmed:volume | 39 | lld:pubmed |
| pubmed-article:7486903 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7486903 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7486903 | pubmed:pagination | 1696-9 | lld:pubmed |
| pubmed-article:7486903 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:7486903 | pubmed:meshHeading | pubmed-meshheading:7486903-... | lld:pubmed |
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| pubmed-article:7486903 | pubmed:meshHeading | pubmed-meshheading:7486903-... | lld:pubmed |
| pubmed-article:7486903 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7486903 | pubmed:articleTitle | Fluconazole resistance due to energy-dependent drug efflux in Candida glabrata. | lld:pubmed |
| pubmed-article:7486903 | pubmed:affiliation | Department of Discovery Biology, Pfizer Central Research, Sandwich, Kent, United Kingdom. | lld:pubmed |
| pubmed-article:7486903 | pubmed:publicationType | Journal Article | lld:pubmed |
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