| pubmed-article:7479960 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7479960 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:7479960 | lifeskim:mentions | umls-concept:C0027793 | lld:lifeskim |
| pubmed-article:7479960 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:7479960 | lifeskim:mentions | umls-concept:C0206249 | lld:lifeskim |
| pubmed-article:7479960 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7479960 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:7479960 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:7479960 | pubmed:dateCreated | 1995-12-28 | lld:pubmed |
| pubmed-article:7479960 | pubmed:abstractText | Ca(2+)-sensitive kinases are thought to play a role in long-term potentiation (LTP). To test the involvement of Ca2+/calmodulin-dependent kinase II (CaM-K II), truncated, constitutively active form of this kinase was directly injected into CA1 hippocampal pyramidal cells. Inclusion of CaM-K II in the recording pipette resulted in a gradual increase in the size of excitatory postsynaptic currents (EPSCs). No change in evoked responses occurred when the pipette contained heat-inactivated kinase. The effects of CaM-K II mimicked several features of LTP in that it caused a decreased incidence of synaptic failures, an increase in the size of spontaneous EPSCs, and an increase in the amplitude of responses to iontophoretically applied alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate. To determine whether the CaM-K II-induced enhancement and LTP share a common mechanism, occlusion experiments were carried out. The enhancing action of CaM-K II was greatly diminished by prior induction of LTP. In addition, following the increase in synaptic strength by CaM-K II, tetanic stimulation failed to evoke LTP. These findings indicate that CaM-K II alone is sufficient to augment synaptic strength and that this enhancement shares the same underlying mechanism as the enhancement observed with LTP. | lld:pubmed |
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| pubmed-article:7479960 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7479960 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7479960 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7479960 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:7479960 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:7479960 | pubmed:author | pubmed-author:NicollR ARA | lld:pubmed |
| pubmed-article:7479960 | pubmed:author | pubmed-author:SoderlingT... | lld:pubmed |
| pubmed-article:7479960 | pubmed:author | pubmed-author:MukherjiSS | lld:pubmed |
| pubmed-article:7479960 | pubmed:author | pubmed-author:LledoP MPM | lld:pubmed |
| pubmed-article:7479960 | pubmed:author | pubmed-author:MalenkaR CRC | lld:pubmed |
| pubmed-article:7479960 | pubmed:author | pubmed-author:HjelmstadG... | lld:pubmed |
| pubmed-article:7479960 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7479960 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:7479960 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:7479960 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7479960 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7479960 | pubmed:pagination | 11175-9 | lld:pubmed |
| pubmed-article:7479960 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7479960 | pubmed:meshHeading | pubmed-meshheading:7479960-... | lld:pubmed |
| pubmed-article:7479960 | pubmed:year | 1995 | lld:pubmed |
| pubmed-article:7479960 | pubmed:articleTitle | Calcium/calmodulin-dependent kinase II and long-term potentiation enhance synaptic transmission by the same mechanism. | lld:pubmed |
| pubmed-article:7479960 | pubmed:affiliation | Department of Cellular and Molecular Pharmacology, University of California, San Francisco 94143-0450, USA. | lld:pubmed |
| pubmed-article:7479960 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7479960 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7479960 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7479960 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7479960 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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