| pubmed-article:7444146 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7444146 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:7444146 | lifeskim:mentions | umls-concept:C0237865 | lld:lifeskim |
| pubmed-article:7444146 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
| pubmed-article:7444146 | lifeskim:mentions | umls-concept:C0041372 | lld:lifeskim |
| pubmed-article:7444146 | lifeskim:mentions | umls-concept:C0205210 | lld:lifeskim |
| pubmed-article:7444146 | pubmed:dateCreated | 1981-2-26 | lld:pubmed |
| pubmed-article:7444146 | pubmed:abstractText | We have applied an in vitro soft-agar tumor-colony assay (which is now applicable to a variety of human cancers) to measurement of in vitro sensitivity to drugs and prediction of clinical response to cancer chemotherapy. The assay predicts drug resistance with 96% accuracy and sensitivity (in healthy pretreated patients) with 62% accuracy. On a pharmacokinetic basis the zone in vitro sensitivity for any given drug was only 5%-10% of the clinical concentration-time product (Cxt) achievable. This suggests that intratumoral drug concentrations in vivo may be lower than those in the plasma, and/or that > 2 log kills of tumor stem cells (not measurable in the assay) are required for clinical response. Serial in vitro studies showed that acquisition of drug resistance is a common clinical phenomenon which can be directly detected and quantitated in vitro. | lld:pubmed |
| pubmed-article:7444146 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7444146 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7444146 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7444146 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7444146 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7444146 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7444146 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7444146 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7444146 | pubmed:issn | 0080-0015 | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:JonesS ESE | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:AlbertsD SDS | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:SalmonS ESE | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:DurieB GBG | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:SoehnlenBB | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:MeyskensF LFL | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:MoorPP | lld:pubmed |
| pubmed-article:7444146 | pubmed:author | pubmed-author:ChenH SHS | lld:pubmed |
| pubmed-article:7444146 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7444146 | pubmed:volume | 74 | lld:pubmed |
| pubmed-article:7444146 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7444146 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7444146 | pubmed:pagination | 300-5 | lld:pubmed |
| pubmed-article:7444146 | pubmed:dateRevised | 2008-2-13 | lld:pubmed |
| pubmed-article:7444146 | pubmed:meshHeading | pubmed-meshheading:7444146-... | lld:pubmed |
| pubmed-article:7444146 | pubmed:meshHeading | pubmed-meshheading:7444146-... | lld:pubmed |
| pubmed-article:7444146 | pubmed:meshHeading | pubmed-meshheading:7444146-... | lld:pubmed |
| pubmed-article:7444146 | pubmed:meshHeading | pubmed-meshheading:7444146-... | lld:pubmed |
| pubmed-article:7444146 | pubmed:meshHeading | pubmed-meshheading:7444146-... | lld:pubmed |
| pubmed-article:7444146 | pubmed:meshHeading | pubmed-meshheading:7444146-... | lld:pubmed |
| pubmed-article:7444146 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7444146 | pubmed:articleTitle | Clinical correlations of drug sensitivity in the human tumor stem cell assay. | lld:pubmed |
| pubmed-article:7444146 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7444146 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7444146 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7444146 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7444146 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7444146 | lld:pubmed |
