| pubmed-article:7406888 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7406888 | lifeskim:mentions | umls-concept:C0026237 | lld:lifeskim |
| pubmed-article:7406888 | lifeskim:mentions | umls-concept:C0022022 | lld:lifeskim |
| pubmed-article:7406888 | lifeskim:mentions | umls-concept:C1327324 | lld:lifeskim |
| pubmed-article:7406888 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:7406888 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:7406888 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7406888 | pubmed:dateCreated | 1980-10-27 | lld:pubmed |
| pubmed-article:7406888 | pubmed:abstractText | Rat and pigeon heart mitochondria supplemented with antimycin produce 0.3-1.0nmol of H(2)O(2)/min per mg of protein. These rates are stimulated up to 13-fold by addition of protophores (carbonyl cyanide p-trifluoromethoxyphenylhydrazone, carbonyl cyanide m-chloromethoxyphenylhydrazone and pentachlorophenol). Ionophores, such as valinomycin and gramicidin, and Ca(2+) also markedly stimulated H(2)O(2) production by rat heart mitochondria. The enhancement of H(2)O(2) generation in antimycin-supplemented mitochondria and the increased O(2) uptake of the State 4-to-State 3 transition showed similar protophore, ionophore and Ca(2+) concentration dependencies. Thenoyltrifluoroacetone and N-bromosuccinimide, which inhibit succinate-ubiquinone reductase activity, also decreased mitochondrial H(2)O(2) production. Addition of cyanide to antimycin-supplemented beef heart submitochondrial particles inhibited the generation of O(2) (-), the precursor of mitochondrial H(2)O(2). This effect was parallel to the increase in cytochrome c reduction and it is interpreted as indicating the necessity of cytochrome c(1) (3+) to oxidize ubiquinol to ubisemiquinone, whose autoxidation yields O(2) (-). The effect of protophores, ionophores and Ca(2+) is analysed in relation to the propositions of a cyclic mechanism for the interaction of ubiquinone with succinate dehydrogenase and cytochromes b and c(1) [Wikstrom & Berden (1972) Biochim. Biophys. Acta283, 403-420; Mitchell (1976) J. Theor. Biol.62, 337-367]. A collapse in membrane potential, increasing the rate of ubisemiquinone formation and O(2) (-) production, is proposed as the molecular mechanism for the enhancement of H(2)O(2) formation rates observed on addition of protophores, ionophores and Ca(2+). | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7406888 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7406888 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7406888 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:7406888 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:7406888 | pubmed:author | pubmed-author:BoverisAA | lld:pubmed |
| pubmed-article:7406888 | pubmed:author | pubmed-author:CadenasEE | lld:pubmed |
| pubmed-article:7406888 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7406888 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7406888 | pubmed:volume | 188 | lld:pubmed |
| pubmed-article:7406888 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7406888 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7406888 | pubmed:pagination | 31-7 | lld:pubmed |
| pubmed-article:7406888 | pubmed:dateRevised | 2010-9-10 | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:meshHeading | pubmed-meshheading:7406888-... | lld:pubmed |
| pubmed-article:7406888 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7406888 | pubmed:articleTitle | Enhancement of hydrogen peroxide formation by protophores and ionophores in antimycin-supplemented mitochondria. | lld:pubmed |
| pubmed-article:7406888 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7406888 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7406888 | lld:pubmed |
