| pubmed-article:7400219 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0596901 | lld:lifeskim |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0206190 | lld:lifeskim |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0031945 | lld:lifeskim |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0039654 | lld:lifeskim |
| pubmed-article:7400219 | lifeskim:mentions | umls-concept:C0332261 | lld:lifeskim |
| pubmed-article:7400219 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:7400219 | pubmed:dateCreated | 1980-10-27 | lld:pubmed |
| pubmed-article:7400219 | pubmed:abstractText | Phorbol myristate acetate (PMA) at a concentration of 0.01 microgram/ml causes an approximately threefold increase in surface area of resident, proteose-peptone-elicited, and thioglycolate-broth-elicited mouse peritoneal macrophages. Resident and proteose-peptone-elicited macrophages, cultured for 24 h in the presence of PMA, increase their pinocytic rate twofold in response to addition of PMA (0.01 microgram/ml) to the medium. Thioglycolate-broth-elicited macrophages, cultured for 24 h in the absence of PMA, immediately increase their pinocytic rate 2- to 3.5-fold in response to a single challenge with PMA (0.01 microgram/ml). Cytochalasin B, colchicine, and podophyllotoxin have only modest inhibitory effects on the basal rate of pinocytosis and on PMA-induced cellular spreading, but completely block the stimulatory effects of PMA on pinocytosis in thioglycolate-broth-elicited macrophages. Cytochalasin D markedly inhibits both basal and PMA-stimulated pinocytosis in these cells. Thus, PMA is a useful tool for studying mechanisms of macrophage spreading and for enhancing the overall rate of pinosome formation. | lld:pubmed |
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| pubmed-article:7400219 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7400219 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7400219 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7400219 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7400219 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:7400219 | pubmed:issn | 0021-9525 | lld:pubmed |
| pubmed-article:7400219 | pubmed:author | pubmed-author:SilversteinS... | lld:pubmed |
| pubmed-article:7400219 | pubmed:author | pubmed-author:WangEE | lld:pubmed |
| pubmed-article:7400219 | pubmed:author | pubmed-author:Phaire-Washin... | lld:pubmed |
| pubmed-article:7400219 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7400219 | pubmed:volume | 86 | lld:pubmed |
| pubmed-article:7400219 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7400219 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7400219 | pubmed:pagination | 634-40 | lld:pubmed |
| pubmed-article:7400219 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7400219 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7400219 | pubmed:articleTitle | Phorbol myristate acetate stimulates pinocytosis and membrane spreading in mouse peritoneal macrophages. | lld:pubmed |
| pubmed-article:7400219 | pubmed:publicationType | Journal Article | lld:pubmed |
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