| pubmed-article:7350533 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C0439849 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C0005210 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C0051356 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C0445223 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C1552599 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C0439836 | lld:lifeskim |
| pubmed-article:7350533 | lifeskim:mentions | umls-concept:C1704787 | lld:lifeskim |
| pubmed-article:7350533 | pubmed:issue | 5742 | lld:pubmed |
| pubmed-article:7350533 | pubmed:dateCreated | 1980-2-26 | lld:pubmed |
| pubmed-article:7350533 | pubmed:abstractText | beta-Endorphin (beta-LPH61-91) is a well known endogenous opioid ligand. It and related peptides have recently been implicated in the control of adaptive behaviour. Smaller beta-endorphin fragments appeared to be more active moieties than the parent molecule in a number of behavioural situations. Their effects seemed to occur independently of interaction with opiate receptor sites in the brain. Moreover, elimination of the opiate-like properties of gamma-endorphin (beta-LPH61-77) by removing the N-terminal amino acid yielded des-tyrosine-gamma-endorphin (beta-LPH62-77, dT gamma E) which had greater behavioural activity than gamma-endorphin. The CNS effects of dT gamma E resembled those of neuroleptic drugs in several test systems. alpha-Endorphin (beta-LPH61-76) exerted effects opposite to those of dT gamma E and in some aspects its activity was comparable to that of psychostimulant drugs. This opposition of effects suggests that a balance between gamma- and alpha-type endorphins is involved in the control of brain function. We report here that either gamma-endorphin and dT gamma E or alpha-endorphin and des-tyrosine-alpha-endorphin (beta-LPH62-76, DT alpha E) can be formed preferentially from beta-endorphin by enzymes associated with an enriched synaptosomal plasma membrane fraction from brain. It is suggested that these enzymes have a role in brain homeostatic mechanisms by regulating the generation of these substances. | lld:pubmed |
| pubmed-article:7350533 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7350533 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7350533 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7350533 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7350533 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7350533 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7350533 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:7350533 | pubmed:author | pubmed-author:VerhoefJJ | lld:pubmed |
| pubmed-article:7350533 | pubmed:author | pubmed-author:de WiedDD | lld:pubmed |
| pubmed-article:7350533 | pubmed:author | pubmed-author:BurbachJ PJP | lld:pubmed |
| pubmed-article:7350533 | pubmed:author | pubmed-author:de KloetE RER | lld:pubmed |
| pubmed-article:7350533 | pubmed:author | pubmed-author:LoeberJ GJG | lld:pubmed |
| pubmed-article:7350533 | pubmed:author | pubmed-author:WiegantV MVM | lld:pubmed |
| pubmed-article:7350533 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7350533 | pubmed:day | 3 | lld:pubmed |
| pubmed-article:7350533 | pubmed:volume | 283 | lld:pubmed |
| pubmed-article:7350533 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7350533 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7350533 | pubmed:pagination | 96-7 | lld:pubmed |
| pubmed-article:7350533 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:meshHeading | pubmed-meshheading:7350533-... | lld:pubmed |
| pubmed-article:7350533 | pubmed:year | 1980 | lld:pubmed |
| pubmed-article:7350533 | pubmed:articleTitle | Selective conversion of beta-endorphin into peptides related to gamma- and alpha-endorphin. | lld:pubmed |
| pubmed-article:7350533 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7350533 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7350533 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7350533 | lld:pubmed |
