| pubmed-article:7259957 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C0034541 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C1511636 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C0871161 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C0048576 | lld:lifeskim |
| pubmed-article:7259957 | lifeskim:mentions | umls-concept:C0069095 | lld:lifeskim |
| pubmed-article:7259957 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7259957 | pubmed:dateCreated | 1981-10-29 | lld:pubmed |
| pubmed-article:7259957 | pubmed:abstractText | 5-Phenoxysulphonyl-1-methyl-4-nitroimidazole (NSC 38087) can act as a sensitizer of hypoxic mammalian cells to radiation in vitro. The degree of sensitization achieved is greater than would be predicted from the drug's electron affinity. Cytotoxicity studies have shown that 5 microM NSC 38087 can reduce the surviving fraction of log-phase V79 cells in air at 37 degrees C to 10(-2) after 2 h exposure. This toxicity is considerably increased by small rises in temperature. In contrast to other nitro-heterocyclic radiosensitizers, NSC 38087 and related 5-substituted 4-nitroimidazoles show greater toxicity towards aerobic than to hypoxic cells. Log-phase cells show the highest sensitivity to the toxic action of NSC 38087, with plateau-phase cells, cells with a history of chronic hypoxia, and thermotolerant cells showing greater resistance. These toxicity data are compared to those for the 2-nitroimidazole hypoxic-cell sensitizer misonidazole. | lld:pubmed |
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| pubmed-article:7259957 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:7259957 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:7259957 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7259957 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:7259957 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:7259957 | pubmed:author | pubmed-author:StratfordI... | lld:pubmed |
| pubmed-article:7259957 | pubmed:author | pubmed-author:HardyCC | lld:pubmed |
| pubmed-article:7259957 | pubmed:author | pubmed-author:WilliamsonCC | lld:pubmed |
| pubmed-article:7259957 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7259957 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:7259957 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7259957 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7259957 | pubmed:pagination | 109-16 | lld:pubmed |
| pubmed-article:7259957 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:7259957 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:7259957 | pubmed:articleTitle | Cytotoxic properties of a 4-nitroimidazole (NSC 38087): a radiosensitizer of hypoxic cells in vitro. | lld:pubmed |
| pubmed-article:7259957 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7259957 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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