| pubmed-article:7255862 | pubmed:abstractText | The effect of various cytochalasins on intestinal glucose absorption in several animals species was investigated in vitro. Glucose absorption in mouse jejunum was highly inhibited (68.1%) by cytochalasin E (25.0 micrograms/ml) within 30-min incubation and less extent in rat (48.9%), hamster (34.1%), frog (28.1%), guinea pig (27.5%), rabbit (24.3%) and turtle jejunum (22.7%). Among cytochalasins A, B, C, D and E, cytochalasin E was a most potent derivative that could inhibit glucose absorption by up to 55.5% at a concentration of only 5.0 micrograms/ml in mouse jejunum and its effect may possibly be related to the formation of mini villi and the intracellular vacuoles in the intestinal absorptive cells. | lld:pubmed |
