| pubmed-article:7196748 | pubmed:abstractText | A clinical pharmacological model to measure the potential difference of the gastric mucosa is reported. The model partially from literature derived has been further developed mathematically. An irritation index is reliable to quantify the protective function of chemical agents. In the reported study Al-acetylsalicylic acid (ASA): The measured parameters (Pdmax, AUB) show that the irritation of the gastric mucosa induced by ASA can be reduced if 100 mg Al-acetylglycyrrhetinate has been predosed. After the instillation of 1000 mg ASA the mean Pdmax amounts to 27.20 [mV] (s = 9.63), the AUB to 930.60 [mV . mins] (s = 311.10). After pre-treatment with Al-acetylglycyrrhetinate the irritation of ASA only produces a Pdmax of 17.80 [mV] (s = 986) and and AUB of 678.60 [mV . min] (s = 374.11). The differences of Pdmax and AUB are significant on the 5% level. The irritation index for 1000 mg ASA amounts to 27.5 [mV2 . min], after pre-treatment with 100 mg Al-acetylglycyrrhetinate it decrease to 14.9 [mV2 . min]. | lld:pubmed |
