| pubmed-article:7194884 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C0001779 | lld:lifeskim |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C0080103 | lld:lifeskim |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C1563743 | lld:lifeskim |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:7194884 | lifeskim:mentions | umls-concept:C1154417 | lld:lifeskim |
| pubmed-article:7194884 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:7194884 | pubmed:dateCreated | 1981-7-9 | lld:pubmed |
| pubmed-article:7194884 | pubmed:abstractText | Growth hormone (GH) release was studied in adults of normal stature, ages 21-86 yr. The subjects were 85-115% of ideal body weight, between the 5th and 95th percentiles in height, and free of active or progressive disease. 9 to 12 individuals in each decade from thirds to ninth were evaluated. The following criteria of GH status were measured: serum GH concentration, analyzed by radioimmunoassay at half-hour intervals for 4 h after onset of sleep, and at 1-h intervals from 8 a.m. to 4 p.m. in 52 subjects; daily retention of N, P, and K in response to 0.168 U human (h)GH/kg body wt3/4/day in 18 subjects; and plasma somatomedin C (SmC) level before and during exogenous hGH treatment in 18 subjects. All 10 individuals, 20-29 yr old, released substantial amounts of endogenous GH during both day and night (average peak serum GH obtained during day and night was 7.3 and 20.3 ng/ml, respectively); average plasma SmC was 1.43 U/ml (95% tolerance limits, 0.64-2.22 U/ml). There was no significant effect of exogenous hGH on elemental balances or on plasma SmC. In contrast, 6 of 12 individuals 60-79 yr old showed the following evidences of impaired GH release; peak waking and sleeping serum GH less than 4 ng/ml; plasma SmC less than 0.38 U/ml; a significant retention in N, P, and K; and a significant rise in plasma SmC, in response to exogenous hGH. Plasma SmC, serum GH during sleep, serum GH during the day, retentions of N, P, and K in response to exogenous hGH, and rise in plasma SmC in response to hGH were all intercorrelated (P less than 0.05). Plasma SmC less than 0.38 U/ml corresponded to peak nocturnal serum GH less than 4 ng/ml. The prevalence of plasma SmC less than 0.38 U/ml increased progressively from age 20 to 90: third decade, 0%; fourth, 11%; fifth, 20%; sixth, 22%; seventh, 42%; eight, 55%; and ninth, 55%. Within each decade, plasma SmC was inversely related to adiposity. | lld:pubmed |
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| pubmed-article:7194884 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7194884 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7194884 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7194884 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7194884 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7194884 | pubmed:month | May | lld:pubmed |
| pubmed-article:7194884 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:7194884 | pubmed:author | pubmed-author:RudmanDD | lld:pubmed |
| pubmed-article:7194884 | pubmed:author | pubmed-author:FlemingG AGA | lld:pubmed |
| pubmed-article:7194884 | pubmed:author | pubmed-author:BaimR SRS | lld:pubmed |
| pubmed-article:7194884 | pubmed:author | pubmed-author:KutnerM HMH | lld:pubmed |
| pubmed-article:7194884 | pubmed:author | pubmed-author:RogersC MCM | lld:pubmed |
| pubmed-article:7194884 | pubmed:author | pubmed-author:LubinM FMF | lld:pubmed |
| pubmed-article:7194884 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7194884 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:7194884 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7194884 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7194884 | pubmed:pagination | 1361-9 | lld:pubmed |
| pubmed-article:7194884 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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