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pubmed-article:7096254pubmed:abstractText4-Hydroxy-3-nitrobenzenearsonic acid (roxarsone) is administered in animal feed as a growth stimulant over a concentration range of 25-50 ppm. The drug is extracted from 5 g feed with 200 mL aqueous 1.0% ammonium carbonate solution and 5 min of mechanical shaking. Undissolved feed particles are allowed to settle and 1.0 mL aliquot of extract is diluted with 9.0 mL 15% methanol solution. This solution is subjected to sample atomization by a graphite furnace and arsenic detection by atomic absorption spectrophotometry (AAS). Roxarsone recovery from nonmedicated commercial feed fortified at 25 ppm was 103.6% with a relative standard deviation (RSD) of 4.0%. Recovery for 50 ppm fortification was 104.5% (RSD 4.3%). Roxarsone assay results by furnace AAS were compared with results by the current AOAC spectrophotometric method and the AOAC total arsenic method. Results by the 3 methods compare well. The procedure was also used to determine other organic arsenicals and inorganic arsenic in laboratory-fortified feed samples; these recoveries were essentially theoretical.lld:pubmed
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pubmed-article:7096254pubmed:monthMaylld:pubmed
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pubmed-article:7096254pubmed:authorpubmed-author:McDonnellJ...lld:pubmed
pubmed-article:7096254pubmed:authorpubmed-author:FrahmL JLJlld:pubmed
pubmed-article:7096254pubmed:authorpubmed-author:GeorgeG MGMlld:pubmed
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pubmed-article:7096254pubmed:volume65lld:pubmed
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pubmed-article:7096254pubmed:pagination711-9lld:pubmed
pubmed-article:7096254pubmed:dateRevised2003-11-14lld:pubmed
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pubmed-article:7096254pubmed:year1982lld:pubmed
pubmed-article:7096254pubmed:articleTitleGraphite furnace atomic absorption spectrophotometric determination of 4-hydroxy-3-nitrobenzenearsonic acid, other organic arsenicals, and inorganic arsenic in finished animal feed.lld:pubmed
pubmed-article:7096254pubmed:publicationTypeJournal Articlelld:pubmed