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pubmed-article:6992227pubmed:abstractTextThe effects of 6-keto-PGE1 on vascular resistance and vascular responses to sympathetic nerve stimulation and vasoconstrictor hormones were investigated in the feline mesenteric vascular bed. Infusions of 6-keto-PGE1 into the superior mesenteric artery dilated the mesenteric vascular bed and markedly inhibited vasoconstrictor responses to sympathetic nerve stimulation, norepinephrine and angiotensin II. The effects of 6-keto-PGE1 and PGE1 on vascular resistance and vasoconstrictor responses were quite similar and both substances inhibited responses to nerve stimulation and pressor hormones in a reversible manner. Responses to nerve stimulation, norepinephrine and angiotensin II were inhibited to a similar extent during infusion of 6-keto-PGE1 and PGE1. Results of these studies suggest that 6-keto-PGE1, a newly identified prostaglandin metabolite, and PGE1 possess the ability to inhibit the vasoconstrictor effects of sympathetic nerve stimulation and pressor hormones by a non-specific action on vascular smooth muscle in the feline small intestine.lld:pubmed
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pubmed-article:6992227pubmed:articleTitleInhibition of vasoconstrictor responses by 6-keto-PGE1 in the feline mesenteric vascular bed.lld:pubmed
pubmed-article:6992227pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:6992227pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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