| pubmed-article:6953448 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6953448 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:6953448 | lifeskim:mentions | umls-concept:C0043210 | lld:lifeskim |
| pubmed-article:6953448 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:6953448 | lifeskim:mentions | umls-concept:C0282636 | lld:lifeskim |
| pubmed-article:6953448 | lifeskim:mentions | umls-concept:C0205161 | lld:lifeskim |
| pubmed-article:6953448 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:6953448 | pubmed:dateCreated | 1982-8-14 | lld:pubmed |
| pubmed-article:6953448 | pubmed:abstractText | The three dominant oxidative biotransformations of estradiol were examined in 10 normal women and 33 females with breast cancer by using a recently devised radiometric method. Estradiol tracers, labeled with 3H specifically in the 17 alpha, C-2, or 16 alpha position, were used to measure both the rate and extent of 17 beta-ol oxidation (the initial metabolic step) and the subsequent 2- and 16 alpha-oxidative reactions. The mean +/- SEM values for the extent of extradiol metabolism at these three specific sites for the extent of estradiol metabolism at these three specific sites were 76.9 +/- 5.3%, 31.1 +/- 4.0%, and 9.3 +/- 0.8%, respectively in normal subjects. Corresponding data in patients with breast cancer--i.e., 73.0 +/- 4.2%, 32.7 +/- 2.7%, and 14.9 +/- 1.5%--revealed a significantly greater extent of 16 alpha-hydroxylation in the latter population. Because the 16 alpha-hydroxylated compounds (including estriol) are themselves potent estrogens, these changes may have important hyperestrogenic consequences that could have a bearing on the etiology of the disease. | lld:pubmed |
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| pubmed-article:6953448 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6953448 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6953448 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6953448 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6953448 | pubmed:month | May | lld:pubmed |
| pubmed-article:6953448 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:SchneiderJJ | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:FishmanJJ | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:BradlowH LHL | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:FracchiaAA | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:AndersonK EKE | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:KinneDD | lld:pubmed |
| pubmed-article:6953448 | pubmed:author | pubmed-author:PierceVV | lld:pubmed |
| pubmed-article:6953448 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6953448 | pubmed:volume | 79 | lld:pubmed |
| pubmed-article:6953448 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6953448 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6953448 | pubmed:pagination | 3047-51 | lld:pubmed |
| pubmed-article:6953448 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6953448 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6953448 | pubmed:articleTitle | Abnormal oxidative metabolism of estradiol in women with breast cancer. | lld:pubmed |
| pubmed-article:6953448 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6953448 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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