| pubmed-article:6895335 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C0013227 | lld:lifeskim |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C1160466 | lld:lifeskim |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C1514468 | lld:lifeskim |
| pubmed-article:6895335 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:6895335 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:6895335 | pubmed:dateCreated | 1982-1-28 | lld:pubmed |
| pubmed-article:6895335 | pubmed:abstractText | Conjugation and cleavage products in the thiolytic metabolism of the anticancer drug 4'-(9-acridinylamino)methanesulfon-m-anisidide were identified primarily by high-pressure liquid chromatography in combination with field desorption mass spectrometry. The spontaneous metabolic pathway of the drug, as related to its susceptibility to nucleophilic attack by endogenous thiols at the 9-carbon atom of the acridine moiety, has been studied. Among the metabolite fraction of 4'-(9-acridinylamino)methanesulfon-m-anisidide excreted in rat bile after administration of a therapeutic dose, a conjugate was identified as the 9-acridinyl thioether of glutathione. This conjugation product and the corresponding 9-acridinyl conjugates were formed spontaneously after incubation of 4'-(9-acridinylamino)methanesulfon-m-anisidide with glutathione, cysteine and N-acetylcysteine in sodium phosphate buffer and other aqueous media, as established by high-pressure liquid chromatography and field desorption mass spectra. The thiolytic pathway results in the release 4-amino-3-methoxymethanesulfonanilide which was identified in all in vitro experiments and in rat serum after intravenous 4'-(9-acridinylamino)methanesulfon-m-anisidide. 9(10H)-Acridone, 9-aminoacridine and other acridine derivatives which occur as minor products during the thiolytic cleavage in vitro were identified by field desorption and partially by high resolution electron impact mass spectrometry. | lld:pubmed |
| pubmed-article:6895335 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6895335 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6895335 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6895335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6895335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6895335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6895335 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6895335 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6895335 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6895335 | pubmed:issn | 0306-042X | lld:pubmed |
| pubmed-article:6895335 | pubmed:author | pubmed-author:AdamsonR HRH | lld:pubmed |
| pubmed-article:6895335 | pubmed:author | pubmed-author:CysykR LRL | lld:pubmed |
| pubmed-article:6895335 | pubmed:author | pubmed-author:ShoemakerDD | lld:pubmed |
| pubmed-article:6895335 | pubmed:author | pubmed-author:PrzybylskiMM | lld:pubmed |
| pubmed-article:6895335 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6895335 | pubmed:volume | 8 | lld:pubmed |
| pubmed-article:6895335 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6895335 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6895335 | pubmed:pagination | 485-91 | lld:pubmed |
| pubmed-article:6895335 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:meshHeading | pubmed-meshheading:6895335-... | lld:pubmed |
| pubmed-article:6895335 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6895335 | pubmed:articleTitle | Identification of conjugation and cleavage products in the thiolytic metabolism of the anticancer drug 4'-(9-acridinylamino)methanesulfon-m-anisidide. | lld:pubmed |
| pubmed-article:6895335 | pubmed:publicationType | Journal Article | lld:pubmed |
