| pubmed-article:6833471 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C0014912 | lld:lifeskim |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C0205216 | lld:lifeskim |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C0870883 | lld:lifeskim |
| pubmed-article:6833471 | lifeskim:mentions | umls-concept:C1522492 | lld:lifeskim |
| pubmed-article:6833471 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:6833471 | pubmed:dateCreated | 1983-5-27 | lld:pubmed |
| pubmed-article:6833471 | pubmed:abstractText | Obesity is associated with an increased incidence of reproductive dysfunction and estrogen-linked diseases. In the present study, we have examined the principal oxidative biotransformations of estradiol in 13 obese premenopausal females and 10 obese males compared to those in 9 premenopausal female and 15 male controls. These studies were carried out using a recently devised, sensitive radiometric method which permits the assessment of the total in vivo oxidative metabolism of estradiol at specific sites (i.e. 17 alpha, 16 alpha, or C-2) on the steroid molecule. Our results indicate that obesity (greater than 60% above ideal body weight) is associated with significant decreases in hydroxylation at C-2 in both sexes (P less than 0.001 for females and P less than 0.02 for males) and in oxidation at 17 alpha in premenopausal females (P less than 0.05) compared to that in age-matched, normal weight controls. Analysis of the plasma 3H2O specific activity curves suggested a slight decrease in the rate of 17-oxidation in obese subjects. The extent of hydroxylation at 16 alpha was not significantly affected by obesity. These metabolic alterations documented in obesity could result in a relative hyperestrogenic state, since, unlike the other estrogen metabolites, the 2-hydroxyestrogen compounds display relatively little peripheral estrogenic activity. This metabolic alteration on a prolonged basis might be contributory to the prevalence of certain hormonally related diseases in obese individuals. | lld:pubmed |
| pubmed-article:6833471 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6833471 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6833471 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6833471 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6833471 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:6833471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6833471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6833471 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6833471 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6833471 | pubmed:month | May | lld:pubmed |
| pubmed-article:6833471 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:6833471 | pubmed:author | pubmed-author:LevinJJ | lld:pubmed |
| pubmed-article:6833471 | pubmed:author | pubmed-author:AndersonKK | lld:pubmed |
| pubmed-article:6833471 | pubmed:author | pubmed-author:SchneiderJJ | lld:pubmed |
| pubmed-article:6833471 | pubmed:author | pubmed-author:FishmanJJ | lld:pubmed |
| pubmed-article:6833471 | pubmed:author | pubmed-author:BradlowH LHL | lld:pubmed |
| pubmed-article:6833471 | pubmed:author | pubmed-author:StrainGG | lld:pubmed |
| pubmed-article:6833471 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6833471 | pubmed:volume | 56 | lld:pubmed |
| pubmed-article:6833471 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6833471 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6833471 | pubmed:pagination | 973-8 | lld:pubmed |
| pubmed-article:6833471 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:6833471 | pubmed:meshHeading | pubmed-meshheading:6833471-... | lld:pubmed |
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| pubmed-article:6833471 | pubmed:meshHeading | pubmed-meshheading:6833471-... | lld:pubmed |
| pubmed-article:6833471 | pubmed:meshHeading | pubmed-meshheading:6833471-... | lld:pubmed |
| pubmed-article:6833471 | pubmed:meshHeading | pubmed-meshheading:6833471-... | lld:pubmed |
| pubmed-article:6833471 | pubmed:meshHeading | pubmed-meshheading:6833471-... | lld:pubmed |
| pubmed-article:6833471 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6833471 | pubmed:articleTitle | Effects of obesity on estradiol metabolism: decreased formation of nonuterotropic metabolites. | lld:pubmed |
| pubmed-article:6833471 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6833471 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6833471 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6833471 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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