| pubmed-article:6815740 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6815740 | lifeskim:mentions | umls-concept:C0178693 | lld:lifeskim |
| pubmed-article:6815740 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:6815740 | lifeskim:mentions | umls-concept:C0085237 | lld:lifeskim |
| pubmed-article:6815740 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:6815740 | lifeskim:mentions | umls-concept:C0599473 | lld:lifeskim |
| pubmed-article:6815740 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6815740 | pubmed:dateCreated | 1983-1-27 | lld:pubmed |
| pubmed-article:6815740 | pubmed:abstractText | Serum from five healthy male volunteers aged 25-36 years was dialyzed against a series of buffer solutions containing varying amounts of racemic tocainide. The concentration of each enantiomer of the drug in the post-dialysis buffer and serum was determined using a specific gas-liquid-chromatographic method. The concentration of total tocainide in the post-dialysis sera ranged from 1.16 to 19.73 micrograms/ml. The percentage of total unbound tocainide ranged from 84.9 +/- 3.3 to 89.9 +/- 2.2 (mean +/- S.D.) whereas the percentages of unbound R-(-) and S-(+) enantiomers ranged from 86.3 +/- 4.0 to 91.0 +/- 2.3 and 83.3 +/- 5.4 to 88.9 +/- 2.2 respectively. Although the binding of the S-(+) enantiomer was slightly but statistically significantly greater than that of the R-(-) isomer, the difference would be of little clinical significance. Binding appeared independent of serum tocainide concentration within the therapeutic range of 4 to 12 micrograms/ml. | lld:pubmed |
| pubmed-article:6815740 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6815740 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815740 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6815740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815740 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6815740 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6815740 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6815740 | pubmed:issn | 0034-5164 | lld:pubmed |
| pubmed-article:6815740 | pubmed:author | pubmed-author:GayGG | lld:pubmed |
| pubmed-article:6815740 | pubmed:author | pubmed-author:BloedowD CDC | lld:pubmed |
| pubmed-article:6815740 | pubmed:author | pubmed-author:SedmanA JAJ | lld:pubmed |
| pubmed-article:6815740 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6815740 | pubmed:volume | 38 | lld:pubmed |
| pubmed-article:6815740 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6815740 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6815740 | pubmed:pagination | 165-8 | lld:pubmed |
| pubmed-article:6815740 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:meshHeading | pubmed-meshheading:6815740-... | lld:pubmed |
| pubmed-article:6815740 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6815740 | pubmed:articleTitle | Serum binding of tocainide and its enantiomers in human subjects. | lld:pubmed |
| pubmed-article:6815740 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6815740 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:6815740 | pubmed:publicationType | In Vitro | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6815740 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6815740 | lld:pubmed |
