| pubmed-article:6799573 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6799573 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:6799573 | lifeskim:mentions | umls-concept:C1517806 | lld:lifeskim |
| pubmed-article:6799573 | lifeskim:mentions | umls-concept:C1566664 | lld:lifeskim |
| pubmed-article:6799573 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:6799573 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:6799573 | lifeskim:mentions | umls-concept:C1514485 | lld:lifeskim |
| pubmed-article:6799573 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6799573 | pubmed:dateCreated | 1982-4-20 | lld:pubmed |
| pubmed-article:6799573 | pubmed:abstractText | The proliferation and differentiation of human leukemic B cells (B-CLL cells) with anti-Ig and T cell-derived helper factors are described. Stimulation of B-CLL cells with anti-Ig and T helper factors could induce proliferation as well as differentiation into IgM- and IgG-producing cells. Neither anti-Ig nor T helper factors alone could induce any proliferation and/or differentiation of B-CLL cells. Not only whole molecules of anti-Ig but also F(ab')2 fragments could induce proliferation and differentiation of B-CLL cells in the presence of T helper factors, but monovalent Fab' fragments were not effective. Induction of both IgM and IgG with the same idiotype was confirmed by immunofluorescent and SDS-PAGE analysis. By employing an IL 2-dependent cytotoxic T cell line and a TRF-responsive B cell line, T cell factors were separated into a fraction with IL2 activity but no TRF activity and a fraction with TRF activity but no IL 2 activity by chromatofocusing. Anti-Ig and IL 2 fraction could induce proliferation of B-CLL cells, but TRF fraction was not effective for the induction of proliferation in anti-IG-stimulated cells. For IgM and IgG production, anti-Ig and both IL 2 and TRF fractions were required. Depletion of IL 2 fraction in the first 2 days' culture inhibited Ig production, whereas the absence of TRF fraction in the first 2 days did not show any inhibitory effect on Ig production. | lld:pubmed |
| pubmed-article:6799573 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6799573 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6799573 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:6799573 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6799573 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:6799573 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:6799573 | pubmed:author | pubmed-author:YamamuraYY | lld:pubmed |
| pubmed-article:6799573 | pubmed:author | pubmed-author:YoshizakiKK | lld:pubmed |
| pubmed-article:6799573 | pubmed:author | pubmed-author:NakagawaTT | lld:pubmed |
| pubmed-article:6799573 | pubmed:author | pubmed-author:KishimotoTT | lld:pubmed |
| pubmed-article:6799573 | pubmed:author | pubmed-author:MuraguchiAA | lld:pubmed |
| pubmed-article:6799573 | pubmed:author | pubmed-author:KaiedaTT | lld:pubmed |
| pubmed-article:6799573 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6799573 | pubmed:volume | 128 | lld:pubmed |
| pubmed-article:6799573 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6799573 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6799573 | pubmed:pagination | 1296-301 | lld:pubmed |
| pubmed-article:6799573 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:6799573 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6799573 | pubmed:articleTitle | Induction of proliferation and Ig production in human B leukemic cells by anti-immunoglobulins and T cell factors. | lld:pubmed |
| pubmed-article:6799573 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6799573 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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