| pubmed-article:678518 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:678518 | lifeskim:mentions | umls-concept:C0327698 | lld:lifeskim |
| pubmed-article:678518 | lifeskim:mentions | umls-concept:C0034792 | lld:lifeskim |
| pubmed-article:678518 | lifeskim:mentions | umls-concept:C0026377 | lld:lifeskim |
| pubmed-article:678518 | lifeskim:mentions | umls-concept:C0392747 | lld:lifeskim |
| pubmed-article:678518 | lifeskim:mentions | umls-concept:C0443172 | lld:lifeskim |
| pubmed-article:678518 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:678518 | pubmed:dateCreated | 1978-10-18 | lld:pubmed |
| pubmed-article:678518 | pubmed:abstractText | A time-dependent increase in ligand affinity has been studied in cholinergic ligand binding to Torpedocalifornica acetylcholine receptor by inhibition of the kinetics of of [125I]-alpha-bungarotoxin-receptor complex formation. The conversion of the acetylcholine receptor from low to high affinity form was induced by both agonists and antagonists of acetylcholine and was reversible upon removal of the ligand. The slow ligand induced affinity change in vitro resembled electrophysiological desensitization observed at the neuromuscular junction and described by a two-state model (Katz, B., & Thesleff, S. (1957) J. Physiol. 138, 63). A quantitative treatment of the rate and equilibrium constants determined for binding of the agonist carbamoylcholine to membrane bound acetylcholine receptor indicated that the two-state model is not compatible with the in vitro results. | lld:pubmed |
| pubmed-article:678518 | pubmed:language | eng | lld:pubmed |
| pubmed-article:678518 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:678518 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:678518 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:678518 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:678518 | pubmed:issn | 0006-2960 | lld:pubmed |
| pubmed-article:678518 | pubmed:author | pubmed-author:LeeTT | lld:pubmed |
| pubmed-article:678518 | pubmed:author | pubmed-author:RafteryM AMA | lld:pubmed |
| pubmed-article:678518 | pubmed:author | pubmed-author:QuastUU | lld:pubmed |
| pubmed-article:678518 | pubmed:author | pubmed-author:BlanchardSS | lld:pubmed |
| pubmed-article:678518 | pubmed:author | pubmed-author:SchimerlikMM | lld:pubmed |
| pubmed-article:678518 | pubmed:author | pubmed-author:WitzemannT... | lld:pubmed |
| pubmed-article:678518 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:678518 | pubmed:day | 13 | lld:pubmed |
| pubmed-article:678518 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:678518 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:678518 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:678518 | pubmed:pagination | 2405-14 | lld:pubmed |
| pubmed-article:678518 | pubmed:dateRevised | 2009-10-27 | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-A... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-F... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-C... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-A... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-C... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-K... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-H... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-P... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-M... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-R... | lld:pubmed |
| pubmed-article:678518 | pubmed:meshHeading | pubmed-meshheading:678518-B... | lld:pubmed |
| pubmed-article:678518 | pubmed:year | 1978 | lld:pubmed |
| pubmed-article:678518 | pubmed:articleTitle | Ligand-induced conformation changes in Torpedo californica membrane-bound acetylcholine receptor. | lld:pubmed |
| pubmed-article:678518 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:678518 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:678518 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:678518 | lld:pubmed |
