| pubmed-article:6756010 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6756010 | lifeskim:mentions | umls-concept:C0443315 | lld:lifeskim |
| pubmed-article:6756010 | lifeskim:mentions | umls-concept:C0021641 | lld:lifeskim |
| pubmed-article:6756010 | lifeskim:mentions | umls-concept:C0000854 | lld:lifeskim |
| pubmed-article:6756010 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:6756010 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:6756010 | pubmed:dateCreated | 1983-1-7 | lld:pubmed |
| pubmed-article:6756010 | pubmed:abstractText | Twenty-four hour plasma free insulin and blood glucose and intermediary metabolite profiles have been measured in 6 C-peptide deficient 'brittle' diabetic patients, during continuous sc and im insulin infusion. During sc infusion free insulin profiles were erratic and unpredictable. Mean 24 h blood glucose levels were raised at 12.6 +/- 2.1 (SE) mmol/l, and 3-hydroxybutyrate at 0.24 +/- 0.08 mmol/l. Blood lactate (1.88 +/- 0.18 mmol/l) and glycerol (0.084 +/- 0.007) were also elevated. Insulin (im) restored free insulin profiles to the normal pattern as found in 'stable' diabetics on sc infusion, with characteristic post-meal peaks (49 +/- 7, 103 +/- 35, and 95 +/- 34 mU/l) and stable night-time levels. Mean 24 h blood glucose was 6.7 +/- 1.1 mmol/l (P less than 0-.05 compared to sc infusion) and 3-hydroxybutyrate 0.07 +/- 0.02 mmol/l (P less than 0.05). Blood lactate (1.67 +/- 0.08 mmol/l) and glycerol (0.10 +/- 0.02 mmol/l) levels remained abnormal. The ratio of plasma free insulin to insulin dose administered was significantly higher during im infusion. In the 6 'stable' diabetics on sc insulin infusion good blood glucose control (7.1 +/- 0.9 mmol/l) was accompanied by clear post-prandial insulin peaks, and stable nocturnal levels. The results strongly suggest that in one category of 'brittle' diabetics there is defective and erratic sc insulin absorption. | lld:pubmed |
| pubmed-article:6756010 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6756010 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6756010 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6756010 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6756010 | pubmed:issn | 0001-5598 | lld:pubmed |
| pubmed-article:6756010 | pubmed:author | pubmed-author:AlbertiK GKG | lld:pubmed |
| pubmed-article:6756010 | pubmed:author | pubmed-author:GillG VGV | lld:pubmed |
| pubmed-article:6756010 | pubmed:author | pubmed-author:Massi-Benedet... | lld:pubmed |
| pubmed-article:6756010 | pubmed:author | pubmed-author:ShepherdG AGA | lld:pubmed |
| pubmed-article:6756010 | pubmed:author | pubmed-author:CapaldoBB | lld:pubmed |
| pubmed-article:6756010 | pubmed:author | pubmed-author:HillF DFD | lld:pubmed |
| pubmed-article:6756010 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6756010 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:6756010 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6756010 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6756010 | pubmed:pagination | 414-20 | lld:pubmed |
| pubmed-article:6756010 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:meshHeading | pubmed-meshheading:6756010-... | lld:pubmed |
| pubmed-article:6756010 | pubmed:year | 1982 | lld:pubmed |
| pubmed-article:6756010 | pubmed:articleTitle | Impaired subcutaneous absorption of insulin in 'brittle' diabetics. | lld:pubmed |
| pubmed-article:6756010 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6756010 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
